摘要
组蛋白3赖氨酸27(histone 3 lysine 27,H3K27)去甲基化酶UTX(ubiquitously transcribed tetratricopeptide repeat on chromosome X,UTX)为X染色体上重复的转录三十四肽,是组蛋白3赖氨酸4(histone 3 lysine 4,H3K4)甲基转移酶复合物MLL2(mixed-lineage leukemia 2,MLL2)中的一员,可调节同源基因HOX(homeobox,HOX)和视网膜母细胞瘤基因RB(retinoblastoma,RB)转录谱系.UTX与BRG1-SWI/SNF重塑复合物(Brg1-containing ATPase-dependent Swi/Snf chromatinremodeling complex,BRG1-SWI/SNF)相互作用促进染色质重塑.因其在细胞的正确再编程、胚胎发育和组织特异性分化中扮演重要角色,UTX失活或缺失会导致癌症、胚胎发育缺陷等疾病的发生.本文将对近年来UTX在胚胎发育及与疾病关系方面的研究进展做一综述.
The ubiquitously transcribed tetratricopeptide repeat on chromosome X（ UTX） was identified as a lysine 27 of histone H3（ H3K27me2 /3） demethylase. UTX is a member of MLL2 H3K4 methyltransferase complex,and its catalytic activity is linked to regulation of HOX and RB transcriptional networks. The interaction between UTX and BRG1-containing SWI / SNF remodeling complex promotes chromatin remodeling. As UTX plays an important role in reprogramming,embryonic development and tissue-specific differentiation,the loss of UTX is closely related to carcinogenesis and developmental disorder. The article would summarize the progress of the studies on UTX in embryonic development and disease.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2015年第11期1138-1145,共8页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家重点基础研究发展计划(973计划
No.2012CB518501)
国家自然科学基金(No.81303018)
江苏省"双创人才"项目
江苏省高校自然科学研究面上项目(No.13KJB360006)~~
