摘要
目的:通过功能磁共振成像(f MRI)研究,实现有氧训练对阿尔茨海默病(AD)治疗效果的量化评估。方法:本研究将选取的17例AD患者随机分为训练组(9例)和对照组(8例),同时获取两组患者在入组时和3月后的f MRI数据,分别对数据进行低频振幅(ALFF)分析和脑功能网络分析。结果:训练组3月后的双侧前额叶、前扣带回皮层ALFF值及脑网络介数中心度(BC)值较训练前增高,且3月后训练组的BC值较对照组增高,差异有统计学意义(P<0.05);进一步根据网络的核心节点分布情况发现,训练后网络的核心节点呈现出双侧分布,有异于训练前的偏侧分布。结论:静息态f MRI数据提示有氧训练有助于AD患者认知功能的恢复,为AD患者有氧训练有效性评价提供了一种量化评估的方法 。
Objective： To evaluate the therapeutic effect of aerobic exercise in patients with Alzheimer＇s disease（AD） quantitatively by functional magnetic resonance imaging （fMRI）. Methods： Seventeen cases of patients with AD were randomly divided into training group（9 cases） and control group（8 cases）. The fMRI data of baseline and 3 months later were got for the amplitude of low frequency fluctuation （ALFF） analysis and analysis of brain functional network. Results： The training group showed increased ALFF value of bilateral prefrontal and anterior cingulate cortex and brain network between centrality（BC） value compared with baseline after 3 months of training, while the BC value of training group was higher than those in con- trol group after 3 months. The difference was statistically significant （P〈0.05）. Further analysis of the network hubs showed bi- lateral distribution after training, which was different from the asymmetric distribution before. Conclusion： Resting-state fMRI data suggest that aerobic exercise is helpful to recovery of cognitive function in patients with AD, providing a quantitative e- valuation method of effectiveness.
出处
《中国临床医学影像杂志》
CAS
北大核心
2015年第11期761-763,767,共4页
Journal of China Clinic Medical Imaging
基金
江苏高校优势学科建设工程资助项目(JX10231801)
关键词
阿尔茨海默病
磁共振成像
Alzheimer disease
Magnetic resonance imaging
