摘要
目的：探讨FOXC1在鼻咽癌组织中的表达及其与临床病理特征的关系。方法收集的101例鼻咽癌组织标本及64例慢性鼻咽黏膜炎性组织标本，采用免疫组织化学SP方法检测鼻咽癌组织及慢性鼻咽黏膜炎性组织中 FOXC1的表达，并分析其表达与患者年龄、性别、临床分期和淋巴结转移的关系。结果FOXC1在鼻咽癌和鼻咽黏膜炎性组织中的表达主要定位于细胞核，但鼻咽癌组织中 FOXC1阳性表达率（84.16％）明显高于慢性鼻咽黏膜炎性组织中FOXC1阳性率（44．44％），差异有统计学意义（χ2＝65．213， P＜0．05）；FOXC1阳性表达率与患者性别、年龄及临床分期无明显关系，差异无统计学意义（P＞0．05），但随着临床分期的增高，FOXC1阳性表达率有随着增高的趋势；有淋巴结转移鼻咽癌患者 FOXC1阳性表达率（86．36％）明显高于无淋巴结转移的鼻咽癌患者FOXC1阳性表达率（69．23％），差异有统计学意义（χ2＝102．568，P＜0．05）。结论 FOXC1在鼻咽癌组织中表达明显上调，在鼻咽癌的发生发展过程中可能发挥着重要的作用，对临床诊断鼻咽癌具有指导意义。
Objective To investigate the relationship of clinical pathological features and FOXC1 expression in NPC tissues.Methods 101 cases of nasopharyngeal tissues and 64 cases of chronic inflammatory nasopharyngeal mucosa tissue were selected and detected by immunohistochemistry SP method,and the relationship between the ex-pression of FOXC1 and the clinical pathological features were analyzed.Results The expression of Foxc1 in nasopha-ryngeal carcinoma and nasopharyngeal mucosa inflammatory tissue mainly located in the nucleus,the positive expres-sion rate （84.16%）in nasopharyngeal carcinoma （NPC）was significantly higher than that in chronic nasopharynge-al mucosa （44.44%）,（χ2 =65.213,P〈0.05）.There was no significant relationship among FOXC1 positive expres-sion and sex,age,and clinical stage.FOXC1 positive expression with lymph node metastasis was higher than that with-out lymph node metastasis.Conclusion The expression of FOXC1 in nasopharyngeal carcinoma tissues is significant-ly up-regulated,which may play an important role in the development of nasopharyngeal carcinoma,and has a guid-ing significance for clinical diagnosis of nasopharyngeal carcinoma.
出处
《中国基层医药》
CAS
2015年第17期2564-2566,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
FOXC1
鼻咽肿瘤
病理
免疫组织化学
FOXC1
Nasopharyngeal neoplasms
Pathology
Immunohistochemistry
