摘要
本文采用队列和队列内病例对照研究的方法，探讨了广西锡矿工人接尘和鼻咽癌高发的关系，队列对象７８１８人，其中，鼻咽癌患者２８例，按年龄、性别配对照１１３例，用ＳＡＳ软件进行单因素分析和多因素非条件Ｌｏｇｉｓｔｉｃ回归分析。结果接尘组鼻咽癌发病的相对危险度为１．４１，Ｐ＞０．０５；病例组与对照组比较ＯＲ＝０．８８，Ｐ＞０．０５；累积接尘量与鼻咽癌发生也未见相关（Ｘ２＝１．３３，Ｐ＞０．０５）。表明：无论是队列资料还是病例对照资料，均不支持职业接尘与鼻咽癌发病有关。但非职业因素中提示：食咸鱼习惯和出生地可能与鼻咽癌发病有关，吸烟、饮酒、婚姻和文化程度等与鼻咽癌发生无关。
A cohort study of 7818 subjects and a nested case-control study of 28 cancer cases and 113 controls were conducted among Guangxi Tin miners to evaluate the relationship between dust-exposed workers and higher incidence from nasopharyngeal cancer. Classical statistic analysis and Non-conditional Logistic Regression with Statistic Analysis System(SAS) were used for analysis. The results showed that the relative risk(RR) of NPC for dust-exposed workers was 1.41 (P>0.05) and the odds ratios(OR) for case-control was 0.85(P>0.05); there existed no dose-respone relationship between cumulative dust exposure for each study subject and incidence from nasopharyngeal cancer. The finding suggested that there was no association between high risk of NPC and dust exposure neither in cohort study nor in case control study. The results of the study also found that the risk of NPC among tin miners was related to salted fish(OR=5.51, P<0.01) and the birth place of males, but not to tobacco, alcohol, marriage or education etc.
出处
《工业卫生与职业病》
CAS
CSCD
1994年第1期25-28,共4页
Industrial Health and Occupational Diseases
关键词
粉尘
鼻咽肿瘤
癌
病因学
nasopharyngeal callcer
dust-exposed
case-control study
