摘要
目的观察补肾化痰方治疗多囊卵巢综合征(PCOS)的临床疗效。方法将62例多囊卵巢综合征高雄激素血症患者随机分为治疗组(30例)和对照组(32例)。对照组予炔雌醇环丙孕酮片口服,治疗组口服补肾化痰方。两组疗程均为3个月经周期,观察临床疗效及不良反应,比较内分泌指标(T、FSH、LH、E2、PRL、P)水平、卵巢体积的变化情况。结果 1治疗组、对照组临床总有效率分别为96.67%和75.00%;组间临床疗效比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,两组T水平、卵巢体积差异均有统计学意义(P<0.05);组间治疗后比较,T水平、卵巢体积差异有统计学意义(P<0.05);停药3个月与本组治疗后比较,对照组T水平、卵巢体积差异有统计学意义(P<0.05);组间停药3个月后比较,治疗组T水平、卵巢体积显著优于对照组(P<0.05)。3治疗前后组内比较,两组LH水平差异有统计学意义(P<0.05);组间治疗后比较,LH水平差异有统计学意义(P<0.05)。4组间不良反应发生率比较,差异有统计学意义(P<0.05)。结论补肾化痰方治疗多囊卵巢综合征的疗效显著并稳定,可明显改善高雄激素血症,促进月经及排卵恢复正常,不良反应较少。
Objective To observe the clinical efficacy of ＂Bushen Huatan Recipe＂ in treating polycystic ovary syndrome （PCOS）. Methods 62 subjects were randomized into treatment group （30 cases） and control group （32 cases）. The control group was treated with Diane-35 orally while the treatment group was treated with ＂Bushen Huatan Recipe＂. The courses of the two groups were 3 menstrual cycles. The clinical effects and adverse reaction were observed, the reproductive endocrinological indicators （ T, FSH, LH, E2 , PRL, P） and the ovarian volume were compared before and after treatment. Results ① The overall effective rate was 96.7% in the treatment group and 75.00% in the control group, with a difference between the two groups （P 〈 0.05 ）. ② Before and after the treatment in each group, there were significant difference in the levels of T （P 〈 0.05 ） ; After the treatment in each group, there were significant difference in T level and the ovarian volume （ P 〈 0.05 ） ; After stop using medicines for 3 months, the levels of T and the volume of ovary in treatment group was better than that in control group （ P 〈 0.05 ）. ③ After treatment, there were significant differences in LH levels in both groups （ P 〈 0.05 ） ; There was significant difference in LH level between the two groups. ④ There was significant difference in adverse reaction between the two groups （ P 〈 0.05 ）. Condus｜on ＂Bushen Huatan Recipe＂ can improve and stabilize clinical symptoms, regulate reproductive endocrine hormone level in PCOS with hyperandrogenism and make patients recover ovulation and promote menstrual bleeding. There was little adverse reaction in the treatment with ＂Bushen Huatan recipe＂.
出处
《上海中医药杂志》
2015年第8期53-55,70,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项(JDZX2012039)
国家中医药管理局中医药行业科研专项(201207001)
