摘要
In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attempt an orthotopic liver transplant into a 3 years old patient suffering from biliary atresia. Thus, the first LT in humans was attempted in a disease, which, up until today, remains the main indication for pediatric LT(p LT). During the last sixty years, refinements in diagnostics and surgical technique, the introduction of new immunosuppressive medications and improvements in perioperative pediatric care have established LT as routine procedure for childhood acute and chronic liver failure as well as inherited liver diseases. In contrast to adult recipients, p LT differs greatly in indications for LT, allocation practice, surgical technique, immunosuppression and postoperative life-long aftercare. Many aspects are focus of ongoing preclinical and clinical research. The present review gives an overview of current developments and the clinical outcome of p LT, with a focus on alternatives to full-size deceased-donor organ transplantation.
In 1953, the pioneer of human orthotopic liver transplantation（LT）, Thomas E Starzl, was the first to attemptan orthotopic liver transplant into a 3 years old patientsuffering from biliary atresia. Thus, the first LT in humanswas attempted in a disease, which, up until today,remains the main indication for pediatric LT （pLT）. Duringthe last sixty years, refinements in diagnostics and surgicaltechnique, the introduction of new immunosuppressivemedications and improvements in perioperative pediatriccare have established LT as routine procedure forchildhood acute and chronic liver failure as well asinherited liver diseases. In contrast to adult recipients,pLT differs greatly in indications for LT, allocation practice,surgical technique, immunosuppression and postoperativelife-long aftercare. Many aspects are focus ofongoing preclinical and clinical research. The presentreview gives an overview of current developments andthe clinical outcome of pLT, with a focus on alternativesto full-size deceased-donor organ transplantation.
