摘要
目的探讨色素性痒疹临床及病理特点,应用米诺环素治疗的远期疗效。方法回顾性分析15例色素性痒疹患者临床及病理资料,随访观察米诺环素治疗的效果。结果本组患者确诊前均误诊,临床表现为躯干部反复发作的瘙痒性风团样或湿疹样皮损,消退后遗留网状色素沉着斑片;其中13例有精神紧张、进食刺激性食物、出汗等诱因或使病情加重的因素;8例行组织病理检查,5例皮损处于活动期,表现为苔藓样皮炎,另3例为消退期,呈非特异性皮炎和/或炎症后色素沉着改变;15例均应用米诺环素（100~200mg/d）治疗,疗程2~6（3.5±1.36）周,均有效;停药后随访3~29个月,7例复发。结论色素性痒疹有特征性临床和病理表现,米诺环素治疗有效,但不能阻止复发。
Objective To study the clinicopathological characteristics of prurigo pigmentosa and long-term therapeutic effect of minocycline.Methods The clinicopathological data were retrospectively analyzed in 15 patients with prurigo pigmentosa and the effect of minocycline was observed.Results All patients were previously misdiagnosed,and were clinically manifested by recurrent pruritic erythematous papules followed by reticulate hyperpigmentation on the trunk,in which 13 had trigger factors such as stress,excitant food and sweating.In 8 patients receiving histopathological examination,5patients were found in the active stage,marked by lichenoid dermatitis,and 3patients were found in the paracmasis stage presenting with nonspecific dermatitis and/or post-inflammatory hyperpigmentation.All patients were effectively treated with minocycline at a dose of 100 to 200mg/day for 2to 6（3.5±1.36）weeks.After follow-up survey for 3to 29 months,7patients recurred.Conclusion Prurigo pigmentosa has characteristic clinicopathological features.Minocycline is effective but could not prevent the recurrence.
出处
《中华实用诊断与治疗杂志》
2015年第5期452-454,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
广东省科技计划社会发展基金项目(2012B031800465)
关键词
色素性痒疹
米诺环素
Prurigo pigmentosa minocycline
