摘要
目的研究雷公藤多甙(TG)对慢性荨麻疹(UC)患者的疗效。方法 2012年2月至2013年3月来该院就诊的UC患者91例,以数字法分成观察组(45例)和对照组(46例)。对照组予以非索非那定治疗,观察组另加服TG,对比两组治疗前后的UAS、VAS、LFS评分和疗效,血清IL-4、IFN-γ及IgE变化及不良反应。结果观察组治疗后的VAS、LFS及UAS评分显著低于治疗前及对照组治疗后的水平,疗效显著高于对照组,IL-4、IgE显著低于治疗前及对照组治疗后水平,IFN-γ显著高于治疗前及对照组治疗后水平,差异均有统计学意义(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论 TG联合非索非那定治疗UC效果好。
Objective To study the effect of tripterygium glycosides（TG）in treating urticaria chronica（UC）.Methods 91 cases of UC in our hospital from February 2012 to March 2013 were randomly divided into the observation group（45 cases）and the con-trol group（46 cases）according to the digital method.The control group was treated with fexofenadine,while on this basis the obser-vation group was added with TG.The UAS,VAS and LFS scores before and after treatment,curative effects,serum IL-4,IFN-γand IgE levels change and adverse reactions were compared between the two groups.Results The VAS,LFS and UAS scores after treatment in the observation group were significantly lower than those before treatment and the control group after treatment;the curative effect after 4-week treatment in the observation group was significantly higher than that in the control group;the IL-4 and IgE levels after treatment in the observation group were significantly lower than those before treatment and the control group after treatment;the IFN-γlevel was significantly higher than that before treatment and the control group after treatment,all the differ-ences above were statistically significant（P〈0.05）.Adverse reactions had no statistically significant difference between two groups （P〉0.05）.Conclusion TG combined with fexofenadine in the treatment of UC has better effect.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第25期3302-3304,共3页
Chongqing medicine
关键词
非索非那定
雷公藤多甙
荨麻疹
慢性病
治疗结果
UAS评分
fexofenadine
tripterygium glycosides
urticaria
chronic disease
treatment outcome
UAS score
