摘要
目的 探讨采用咪喹莫特乳膏对尖锐湿疣免疫调节作用以及复发率的情况.方法 将尖锐湿疣患者80例随机分为观察组和对照组,各40例.对照组给予激光治疗;观察组在激光治疗后给予咪喹莫特乳膏治疗.结果 观察组治疗总有效率为92.50％,对照组患者治疗总有效率为80.0％,观察组治疗后复发率为12.50％,而对照组复发率为40.00％,差异具有统计学意义（P＜0.05）.治疗后,观察组患者IL-4和IL-10水平低于对照组患者IL-4和IL-10水平,且观察组患者IL-12和IFN-γ水平高于对照组患者IL-12和IFN-γ水平,差异具有统计学意义（P＜0.01）.治疗后观察组患者CD ＋4、CD ＋4/CD ＋8、NK水平均高于对照组患者CD ＋4、CD＋ 4/CD＋8、NK水平,差异具有统计学意义（P＜0.01）.观察组患者CD＋8水平低于对照组患者CD ＋8水平,差异具有统计学意义（P＜0.01）.治疗6个月后,观察组尖锐湿疣复发患者的CD＋3、CD＋4、CD＋ 4/CD＋8以及NK水平低于未复发患者CD＋3、CD＋4、CD＋ 4/CD＋8以及NK水平;且复发患者的CD ＋8水平高于未复发患者CD ＋8水平,差异具有统计学意义（P＜0.05）.结论 咪喹莫特乳膏治疗尖锐湿疣疗效显著,可有效降低复发率,提高患者细胞免疫调节作用是防止尖锐湿疣复发的重要机制.
Objective To investigate the immunomodulatory effects and recurrence influence of imiquimod cream for treating patients with condyloma acuminatum.Methods 80 patients with genital warts were randomly divided into the observation group and the control group,40 cases in each.Control group was given laser treatment and observation group was given imiquimod cream treatment after laser treatment.Resuits The total effective rate of the the observation group was 92.50% and 80.0% of the control group.The difference was statistically significant （P 〈 0.05）.After treatment,IL-4 and IL-10 levels of the observation group were lower than those of the control group.IL-12 and IFN-γ levels in the observation group were higher than those in the control group.The difference was statistically significant （P 〈 0.01）.After treatment,CD ＋4,CD ＋ 4 /CD ＋ 8,NK levels in the observation group were higher than those of in the control group.The difference was statistically significant （P 〈 0.01）.CD ＋ 8 level in the observation group was lower than that in the control group,and the difference was statistically significant （P 〈 0.01）.After 6 months treatment,CD ＋ 3,CD ＋ 4,CD ＋4/CD ＋ 8 and NK levels of the observation group were lower than those of the control group.CD ＋ 8 level of relapse patients were higher than that of patients without recurrence and the difference was statistically significant （P 〈 0.05）.Conclusions The clinical effect of imiquimod in treatment of genital warts was significant,which can effectively reduce the recurrence rate and improve the patient cell immunomodulatory function,and prevent the recurrence of genital warts.
出处
《国际病毒学杂志》
2015年第2期133-136,共4页
International Journal of Virology
