摘要
目的探讨血清可溶性肿瘤坏死因子样凋亡微弱诱导剂（sTWEAK）和胱抑素C联合检测早期糖尿病肾病（DN）的临床意义。方法选取2012-2013年DN患者35例（DN组）,糖尿病（DM）患者56例（DM组）及体检健康者40例（健康对照组）,检测血清sTWEAK和胱抑素C水平,并检测DM组患者糖化血红蛋白（HbA1c）水平及尿蛋白定性。结果 DN组血清sTWEAK水平低于DM组,胱抑素C水平高于DM组;DM组及其尿蛋白阴性者血清sTWEAK水平低于健康对照组,胱抑素C水平高于健康对照组,差异均有统计学意义（P〈0.05）。DM组HbA1c〉10%者血清胱抑素C水平高于HbA1C〈10%者,血清sTWEAK低于HbA1C〈10%者,差异均有统计学意义（P〈0.05）。结论血清sTWEAK和胱抑素C联合检测可作为早期诊断DN的较敏感指标,对判断早期DN的发生和发展有重要意义。
Objective To investigate the clinical significance of combined detection of serum sTWEAK and cystatin C in early di‐abetic nephropathy （DN） .Methods 35 patients with DN（DN group） ,56 patients with diabetes mellitus （DM ,DM group） and 40 healthy cases conducted physical examination （healthy control group） were selected and serum levels of sTWEAK and cystatin C were detected .And levels of glycosylated hemoglobin（HbA1c） and qualitative urine protein test were conducted in DM group .Results The serum sTWEAK level in DN group was lower than that in DM group ,and the serum cystatin C level was higher than that in DM group（P〈0 .05） .The serum levels of sTWEAK in DM group and DM patients with negative qualitative urine protein were lower than that in healthy control group ,while the serum cystatin C levels were higher than that of control group （P〈0 .05） . Compared with DM patients with HbA1C〈 10% ,the serum cystatin C level was higher and serum sTWEAK level was lower of those with HbA1c〉10% （P〈0 .05） .Conclusion The combined detection of serum sTWEAK and cystatin C could be a sensitive index for early diagnosis of DN ,with important significance in the occurrence and development of DN .
出处
《国际检验医学杂志》
CAS
2015年第8期1082-1083,共2页
International Journal of Laboratory Medicine
