急性冠脉综合征患者血清sTW EAK水平与冠脉病变严重程度的关系被引量：1

Research of the relationship between sTWEAK and severity of coronary atherosclerosis in patients with Acute coronary syndrome

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摘要目的:探讨血清可溶性肿瘤坏死因子样凋亡微弱诱导剂(sTWEAK)水平在冠状动脉粥样硬化病变中的变化及临床意义。方法:选择166例患者,依据冠状动脉造影结果分为正常对照组52例、轻度病变组30例、中度病变组40例和重度病变组44例,于入院第1天空腹抽血检测sTWEAK浓度及血脂、超敏C-反应蛋白(hs-CRP)等指标,应用统计学方法探讨这些指标与冠脉病变严重程度的关系。结果:冠脉重度病变组患者血hs-CRP、低密度脂蛋白(LDL-C)、三酰甘油(TG)等显著高于其余三组,HDL水平则在重度病变组明显降低。随着冠脉病变程度加重,sTWEAK浓度逐渐增高。急性冠脉综合征患者外周血sTWEAK水平与冠状动脉粥样硬化严重程度呈正相关。结论:血sTWEAK浓度可能是评价冠心病患者冠脉病变严重程度的指标之一。 Objective To study on serum soluble tumor necrosis factor-lke weak inducer of apoptosis（Stweak） levels in coronary atherosclerosis and its clinical significance.Methods 166 cases with acute coronary syndrome（ACS） were divided into 4 treatment groups：52 cases in control group,30 cases in mild lesions group,40 cases in moderate lesions group,and 44 cases in severe lesions group.Serum sTWEAK concentration was determined by ELISA.Severity of coronary atherosclerosis was estimated by Gensini scoring.Results Serum hs-CRP、LDL-C、TG and sTWEAK concentration are significantly increased in severe lesions group compared with those in other groups.The sTWEAK concentration had a positive correlation with severity of coronary atherosclerosis.Conclusion Evaluation of the serum sTWEAK concentration may be one of the indicators of the severity of coronary lesion in patients with coronary atherosclerotic heart disease.

作者陈霞徐戈孙文静马冰宁张晶晶李华华雷敏

机构地区广西医科大学第一附属医院广西玉林市红十字会医院

出处《吉林医学》 CAS 2014年第18期3907-3909,共3页 Jilin Medical Journal

基金广西科学研究与技术开发计划课题[课题编号:桂攻科1140003A-20]

关键词冠状动脉粥样硬化肿瘤坏死因子样凋亡微弱诱导剂急性冠脉综合征 Coronary atherosclerosis Stweak Acute coronary syndrome

分类号 R541.4 [医药卫生—心血管疾病]

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1Giuseppe Patti,Vincenzo Pasceri,Giuseppe Colonna,et al.Atrorvastatin pretreatment improves outcomes in patrints with acute coronary syndromes undergoing early percutaneous coronary intervention[J].Journal of the American College of Cardiology,2007,49(12):1272.
2马梅,尹浩晔,贾文军,高雪梅,刘克强,孟东.不同冠状动脉评分方法评价冠心病严重程度的关系研究[J].中国循环杂志,2007,22(5):340-342. 被引量：28
3林财威,张海澄,田江华,卢明喻,刘健,王伟民.冠脉评分法在急性心肌梗死应用中的相关性[J].临床心电学杂志,2011,20(4):253-254. 被引量：3
4Wang Shihan,Wang Jie,Li Ji.Relationship between the Gensini Score of Blood Stasis Syndrome in Coronary Heart Disease and VDGF[J].World Science and Technology/Modernization of Traditional Chinese Medicine and Materia Medica,2010,3(8):355.
5Aristoteli LP,Moller HJ,Bailey B,et al.The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis[J].Atherosclerosis,2006,184(2):342.
6Burkly LC,Michaelson JS,Hahm K,et al.Role of TWEAK/Fn14pathway in health and disease[J].Cytokine,2007,28(1):1.
7Begona Munoz-Garcia,Juan Antonio Moreno,Oscar LopezFranco,et al.Tumor Necrosis Factor-Like Weak Inducer of Apoptosis(TWEAK)Enhances Vascular and Renal Damage Induced by Hyperlipidemic Diet in ApoE-Knockout Mice[J].Arterioscler Thromb Vasc Biol,2009,29(11):2061.
8郝赫,关立克.JAK-STAT信号通道在动脉粥样硬化中的意义[J].吉林医学,2013,34(1):123-125. 被引量：7
9Roos C,Wicovsky A,Mullev N,et al.Soluble and transmembrane TNF-like weak inducer of apoptosis differentially active the classical and noncanonical NF-kappa B pathway[J].J Immunol,2010,185(3):1593.
10EI-Shehaby A,Danweesh H,EI-khatib M,et al.Correlations of urinary biomarkers,TNF-like weak inducer of apoptosis(TWEAK),ost eoprotegerin(OPG),monocyte chemoattractant protein-1(MCP-1),and IL-8 with lupus nephritis[J].J Clin Immunol,2011,31(5):848.

二级参考文献8

1Leaman DM, Brower RW, Meester GT, et al. Coronary artery atherosclerosis severity of the disease, severity of angina pectoris and compromised left ventricular function. Circulation 1981;63: 285-299.
2Gensini GG. A more meaningful scoring system for determining the severity of coronary of coronary heart disease letter. Am J Cardiac 1953;51:606-611.
3Leaman DM,Brower RW,Meester GT,et al.Coronary artery atherosclerosis:severity of the disease,severity of angina pectoris and compromised left ventricular function.Circulation,1981,63:285-299.
4Gensini GG.A more meaningful scoring system for determining the severity of coronary of coronary heart disease (letter).Am J Cardiol,1983,51:606.
5Guidelines for coronary angiography.A report of the American College of Cardiology/American Heart Association Task Force on assessment of diagnostic and therapeutic cardiovascular procedures(subcommittee on coronary angiography).J Am Coll Cardiol,1987,10:935-950.
6Eigler N,Pfaff JM,Whiting J,et al.The role of digital angiography in the evaluation of coronary artery disease.Int J Cardiol,1986,10:3-13.
7Spears JR,Sandor T,Als AV,et al.Computerized image analysis for quantitative measurement of vessel diameter from cineangiograms.Circulation,1983,68:453-461.
8高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志,2001,29(12):710-725. 被引量：5093