摘要
目的 :了解江苏省首次接受艾滋病免费抗病毒治疗的HIV/AIDS患者治疗1年后CD4+T变化及影响因素。方法 :收集江苏省首次接受抗病毒治疗的基线和治疗随访1年时均有CD4+T细胞检测结果记录的HIV/AIDS患者资料,随访截止时间为2014年5月31日。建立Excel数据库并用SPSS16.0软件进行分析。结果:首次接受抗病毒治疗的基线和随访1年时均有CD4+T检测结果记录的HIV/AIDS共3 290例。81.4%为江苏省籍,男女比例为4.36∶1,平均年龄(39.7±12.1)岁。感染途径主要为性传播。入组时基线CD4+T细胞计数均数为185.81个/μl。治疗1年后的CD4+T细胞均数为312.20个/μl。Logistic回归分析显示,年龄大、基线CD4+T高、在疾控中心治疗和临床Ⅰ期的HIV/AIDS患者,其CD4+T较基线增长值≥100个/μl的比例低。结论:江苏省HIV/AIDS抗病毒治疗对免疫功能恢复效果显著,应继续规范、早期开展抗病毒治疗工作。
Objective：To analyze the CD4^＋T variation and its impact factors on the HIV/AIDS,who initially had received highly active antiretroviral therapy （HAART） for 1 year in Jiangsu province. Methods：According to the baseline and follow-up data of HIV/AIDS initially receiving HAART with the CD4^＋T cell count tested in baseline and 1 year after treatment,the deadline of the follow-up was on May 31,2014. Excel database was established and statistical analysis was performed using SPSS 16.0 software. Results：There were 3 290 patients initially receiving HAART with the CD4^＋ T cell count tested in baseline and 1 year after treatment totally. Eighty-one point four percent of them were from local province; the ratio of male to female was 4.36：1; the average age was 39.7 ± 12.1 years old; 92.3% of the patients were infected with HIV through sexual transmission; the mean CD4^＋ T cell count of cases was 185.81 cells/μl in baseline,and it increased to 312.20 cells/μl 1 year after treatment and significant differences were found. The age, CD4^＋T baseline, WHO disease stage,treatment site and regimen influenced the growth value of CD4^＋ T. Conclusion： HIV/AIDS treatment has a remarkable effect on immunological function rehabilitate for pationts in Jiangsu province. Standardized and early treatment still should he strengthened.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2015年第3期425-429,432,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
十二五国家科技重大专项(2013ZX10004-905)
江苏省卫生厅医学重点人才项目(RC2011086
RC2011087)
江苏省预防医学课题(Y2012069)
