摘要
目的分析人口学特征、感染途径与CD4^+T淋巴细胞绝对值的关系,为连云港市HIV/AIDS病例临床分期、机会性感染风险评估及抗病毒治疗提供参考依据。方法应用SPSS 19.0软件包Excel 2007对数据进行统计分析,将人口学特征和感染途径纳入统计变量,两组间比较用t检验,多组间比较用方差分析。结果252例新报告病例以男性为主,占86.5%;年龄集中在29岁以下,占88.5%,超过50岁极少,占1.6%;文化程度以初中及以上为主,占84.9%;婚姻状况以未婚和已婚有配偶者为主,分别为未婚占38.5%、已婚有配偶占52.4%;感染途径同性和异性占主导,分别为51.6%和48.0%,母婴垂直传播仅占0.4%。首次CD4^+T淋巴细胞绝对值检测均值为(401.5±255.2)个/μl。个体差异较大,最小值0个/μl,最大值1388个/μl。组间病例差异不大,其中小于200个/μl占22.2%;200~349个/μl占21.8%;350~499个/μl占25.4%;≥500个/μl占30.6%。结论通过对CD4^+T淋巴细胞计数分析,连云港市HIV感染者存在一定比例晚发现艾滋病病人。建议艾滋病防治知识力争做到制度化、让HIV感染者及时检测CD4^+T淋巴细胞,为临床分期、机会性感染风险评估及抗病毒治疗提供参考依据。
Objective To analyze the relationship between demographic characteristics,infection pathway and absolute value of CD4^+T lymphocytes,and to provide reference for clinical staging,opportunistic infection risk assessment and antiviral treatment of HIV/AIDS cases in Lianyungang City.Methods Statistical analysis was performed using SPSS 19.0 software package and Excel2007.Demographic characteristics and infection pathways were included in statistical variables.The t test was used for comparison between the two groups,and the variance analysis was used for comparison between groups.Results A total of 252 newly reported cases were mainly male,accounting for 86.5%.The age was concentrated below 29 years old,accounted for 88.5%,while only 1.6 percent were over 50 years old.The education level was mainly junior high school and above,accounting for 84.9%.The marital status was dominated by unmarried and married with spouse,accounting for 38.5%and 52.4%,respectively.The infection pathways dominated by the same sex and the opposite sex,accounting for 51.6%and 48.0%respectively,while mother-to-child vertical transmission accounted for only 0.4%.The mean absolute value of CD4^+T lymphocytes detected at the first time was(401.5±255.2)/μl.Individual differences were large,with a minimum of 0/μl and a maximum of 1388/μl.There were no significant differences between the two groups,of which less than 200/μl accounted for 22.2%,200~349/μl accounted for21.8%,350~499/μl accounted for 25.4%,≥500/μl accounted for 30.6%.Conclusion Through the analysis of CD4^+T lymphocyte counts,there is a certain proportion of HIV-infected patients in Lianyungang City who are found to be AIDS patients later.It is suggested that the knowledge of AIDS prevention and treatment should be institutionalized and CD4^+T lymphocytes should be detected timely in HIV-infected patients,so as to provide references for clinical staging,risk assessment of opportunistic infection and antiviral treatment.
作者
徐大叶
张笑
朱晓露
XU Daye;ZHANG Xiao;ZHU Xiaolu(Lianyungang Center for Disease Control and Prevention,Jiangsu210003,China)
出处
《医学动物防制》
2020年第3期226-229,共4页
Journal of Medical Pest Control
基金
连云港市卫生计生科技项目(2016028).
