摘要
目的探讨儿童甲状腺癌与自身免疫性甲状腺疾病之间的关系。方法回顾性分析2000年至2008年行甲状腺切除术并经病理确诊为甲状腺癌的68例患儿的临床资料,比较伴发与不伴发自身免疫性甲状腺疾病的甲状腺癌患儿的年龄、性别、结节大小、淋巴结转移、侵袭状态等临床及病理特征。结果 68例甲状腺癌患儿中,31例(45.6%)伴发自身免疫性甲状腺疾病;与37例未伴发自身免疫性甲状腺疾病的患儿相比,伴发自身免疫性甲状腺疾病患儿中女性比例更高、年龄更大、结节直径更小、促甲状腺激素水平和甲状腺球蛋白水平更高、生存时间更短,无病生存比例低、复发率高,差异均有统计学意义(P<0.05)。结论儿童自身免疫性甲状腺疾病与甲状腺癌的关系密切,对自身免疫性甲状腺疾病患儿应加强随访。
Objective To investigate the relationship between autoimmune thyroid disorders（AITD） and thyroid cancer（TC） in children.Methods Clinical date from 68 patients who underwent thyroidectomy and were histologically confirmed with TC were retrospectively analyzed from 2000 to 2008.Age,gender,nodular size,lymph node metastasis,and invasive status of thyroid cancer were compared between patients with and without AITD.Results In 68 patients with TC,45.6%（31/68） patients had concurrent AITD.Compared with those without AITD,a greater female preponderance,older age,smaller tumour size,higher TSH values,higher TG values,shorter survival time,lower disease free survival rate,and higher relapse rate were found in patients with AITD（P〈0.05）.Conclusions AITD are associated with TC in children.Follow-up is suggested in children with AITD.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2015年第3期238-241,共4页
Journal of Clinical Pediatrics
