摘要
目的分析儿童及青少年分化型甲状腺癌(DTC)131I治疗对血常规、肝功能及甲状旁腺的短期影响。方法收集60例在我科接受131I治疗的儿童及青少年DTC患者血常规、肝功能、甲状旁腺激素(PTH)及降钙素(CT),对治疗前后结果进行配对t检验。结果131I治疗1个月后血常规白细胞(WBC)、红细胞(RBC)、血红蛋白(HGB)、血小板(PLT)下降(P<0.001)。治疗后3个月仅PLT下降(P<0.001),其余指标差异均无统计学意义(P>0.05)。治疗后1周、6个月WBC、RBC、HGB、PLT差异无统计学意义(P>0.05)。治疗后1、3、6个月天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)与治疗前比较差异无统计学意义(P>0.05)。治疗后3、6个月甲状旁腺激素(PT)、降钙素(CT)与治疗前比较差异无统计学意义(P>0.05)。结论131I治疗儿童及青少年分化型DTC对血常规有短暂影响,短期内可恢复,对肝功能、甲状旁腺无明显短期影响,所以131I治疗儿童及青少年DTC患者短期内是相对安全的。
Objective To analyze the short-term effects of 131I treatment on routine blood test,liver function and parathyroid gland in children and adolescents with differentiated thyroid carcinoma(DTC). Methods Data of routine blood examination,liver function,parathyroid hormone(PTH)and calcitonin(CT)were collected and recorded from 60 children and adolescents with differentiated thyroid cancer who treated in our department and the data were tested by paired t test before and after the treatment. Results The level of WBC,RBC,HGB and PLT after 1 month of 131I therapy reduced than that before the treatment and it had statistical difference(P < 0.001).After 3-month treatment,only PLT was significantly different from that before the treatment(P < 0.001),but the other indexes were not statistically significant(P > 0.05). The level of WBC,RBC,HGB and PLT had no statistical significance 1 week and 6 months after the treatment(P > 0.05). There was no significant difference in aspartate aminotransferase(AST),alanine aminotransferase(ALT)after 1-,3-and 6-month treatment(P > 0.05).PTH and CT had no significant difference after 3-and 6-month treatment(P > 0.05). Conclusion 131I treatment of DTC in children and adolescents has a temporary effect on routine blood test,which could recover in a short period of time,but has no obvious effect on liver function and parathyroid gland,so 131I is safe for children and adolescents with DTC.
作者
申沛于
韦智晓
李俊红
韦海莲
SHEN Peiyu;WEI Zhixiao;LI Junhong;WEI Hailian(Depart ment of Nuclear Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第19期3067-3070,共4页
The Journal of Practical Medicine
基金
广西医疗卫生适宜技术研究与开发项目（编号：S201415-06）
关键词
儿童及青少年
分化型甲状腺癌
131I
血常规
肝功能
甲状旁腺激素
children and adolescents
differentiated thyroid carcinoma
131I
blood routine
liver function
parathyroid gland
