摘要
黑皮质素受体4(MC4R)是G-蛋白耦联受体(GPCR),是下丘脑分泌的一种肽类物质,在调控动物采食量中起着重要的作用。MC4R与阿黑皮质素原(POMC)分泌的α-促黑素(α-MSH)结合,激活下丘脑MC4R神经元的表达,从而抑制采食量。本文综述了MC4R的生物学特征及其在动物采食量调控中的作用机理,并阐述了影响MC4R活性的因素。
The melanocortin-4 receptor （ MC4R） is a typical G protein-coupled receptor （ GPCR） which pres-ents in the hypothalamus as a peptide, and plays an important role in feed intake regulation. It combines withα-melanocyte-stimulating hormone （α-MSH） which is secreted from pro-opiomelanocortin （ POMC） and acti-vates the expression of MC4R neuron to depress the feed intake of animals. The biological characteristics of MC4R and its mechanism in feed intake regulation were reviewed in the article.
出处
《动物营养学报》
CAS
CSCD
北大核心
2015年第3期683-690,共8页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金(31101253
30973112)
关键词
黑皮质素受体-4
生物学特征
采食量调控
作用机理
melanocortin-4 receptor
biological characteristics
feed intake regulation
mechanism
