摘要
目的研究早产儿感染性疾病血浆皮质醇、促肾上腺皮质激素(ACTH)的变化。方法该院新生儿科早产儿90例,分为对照组30例,轻度感染组30例,重度感染组30例。所有病例均于出生后第1、3、7天应用放射免疫分析法检测各组血清皮质醇、ACTH水平并做相应比较。结果轻度感染组早产儿第1、3、7天皮质醇水平分别为(193.04±39.48)、(151.12±35.62)、(128.37±27.47)ng/mL,第1天水平高于第3、7天,差异有统计学意义(P<0.05),第3天高于第7天,差异有统计学意义(P<0.05)。重度感染组第1、3、7天皮质醇水平分别为(99.43±50.17),(96.52±44.69),(131.13±42.73)ng/mL,第1、3天明显低于第7天,差异有统计学意义(P<0.05)。结论早产儿重度感染的早期存在相对性肾上腺皮质功能不全,表现为血浆皮质醇水平下降,第7天皮质醇可恢复正常。而血浆ACTH水平与感染无相关。
Objective To investigate the changes of plasma cortisol and adrenocorticotrophic hormone（ACTH）levels in premature neonates with the infectious diseases.Methods Ninety premature neonates in the neonatal department of our hospital were divided into the control group（30cases）,mild infection group（30cases）and severe infection group（30cases）.The radioimmunoassay was adopted to detect the serum cortisol and ACTH levels on 1,3,7dafter birth in all subjects and the corresponding comparison was conducted.Results The cortisol levels on 1,3,7din the mild infection group were（193.04±39.48）,（151.12±35.62）,（128.37±27.47）ng/mL respectively,the level on 1dwas higher than that on 3,7d（P〈0.05）,and the 3dwas higher than that on 7d（P〈0.05）.The cortisol level on 1,3,7din the severe infection group were（99.43±50.17）,（96.52±44.69）,（131.13±42.73）ng/mL respectively,and the level on 1,3dwas significantly lower than that on 7d（P〈0.05）.Conclusion The relative adrenocortical insufficiency exists in premature neonates with the early stage of severe infection and is manifested by the decline of plasma cortisol level,which could recover to the normal level on 7d,but the plasma ACTH level has no relation with infection.
出处
《国际检验医学杂志》
CAS
2015年第5期643-644,共2页
International Journal of Laboratory Medicine
基金
深圳市宝安区科技计划社会公益项目(2012010)
关键词
感染
早产儿
肾上腺皮质功能不全
infection
premature infant
adrenocortical insufficiency
