摘要
目的探讨血清胃蛋白酶原Ⅱ(PGⅡ)在不同疾病中的血清表达水平及其与幽门螺杆菌(H.pylori)感染的关系。方法本研究共纳入2004年于庄河市中心医院就诊的患者565例,应用酶联免疫吸附测定法(ELISA)检测血清PGⅡ水平以及H.pyloriIg G抗体(H.pylori-Ig G)滴度。结果在≤60岁人群、H.pylori-Ig G阴性人群及浅表性胃炎(SG)组中,女性患者血清PGⅡ水平均显著低于男性(P<0.05);在萎缩性胃炎(AG)组中,女性患者血清PGⅡ水平与男性相比存在升高的趋势(P<0.05)。在SG组、胃糜烂溃疡(GEU)组、AG组及胃癌(GC)组中,H.pylori阳性患者血清PGⅡ水平均显著高于H.pylori阴性患者(P<0.0005)。在总人群中,与SG组相比,GEU组血清PGⅡ水平显著升高(P=0.010)。在H.pylori阳性人群中,与SG组相比,GEU组血清PGⅡ水平显著升高(P=0.006);与GEU组相比,AG组PGⅡ水平显著降低(P=0.029)。结论血清PGⅡ水平受患者性别及H.pylori感染等相关因素的影响,在从浅表性胃炎、胃糜烂溃疡、萎缩性胃炎到胃癌的动态变化过程中呈现先升高后降低的趋势。血清PGⅡ作为胃黏膜分化成熟的标志物,其表达水平有望成为胃疾病筛查及早期诊断的一个重要检测指标,尤其是对于H.pylori感染相关胃疾病具有较好的提示作用。
Objective To investigate the association between serum PGⅡ levels and gastric diseases and H. pylori infection. Methods In 2004,a total of 565 participants were selected and enrolled in this study. PGⅡ and H. pyloriIg G were measured by enzyme-linked immuno-sorbentassay（ ELISA） method. Results The level of serum PGⅡ in females was significantly higher than that in males in those ≤60 years,negative status of H. pylori-Ig G group,and in superifical gastritis（ SG） individuals（ P〈 0. 05）. The level of serum PGⅡ was higher in H. pylori seropositive individuals than in H. pylori seronegative individuals with SG,gastric erosion and ulcer（ GEU） atrophic gastritis（ AG） and gastric cancer（ GC）（ P 〈0. 05）. In total samples,PGⅡ was significantly higher in GEU than that in SG group（ P = 0. 010）.In H. pylori seropositive individuals,the serum PGⅡ was significantly higher in GEU group than that in SG group（ P =0. 006）. Compared with GEU group,the serum PGⅡ was significantly lower in AG（ P = 0. 029）. Conclusion The levels of serum PGⅡ is influenced by the gender and the status of H. pylori infection. The level of PGⅡ is raised first and then reduce in the progression from SG,GEU,AG to GC. As a mature marker of gastric epithelia,it may be an important indicator in H. pylori related disease.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第2期166-169,共4页
Chinese Journal of Gastroenterology and Hepatology
