摘要
目的:探讨白细胞介素-6(interleukin 6,IL-6)、超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)与老年轻度认知功能障碍(mild cognitive impairment,MCI)的相关性。方法:100名老年健康者作为对照组,同期100例老年MCI患者为病例组,2组间高血压、糖尿病、吸烟、血脂、饮酒、文化程度、体质量指数等无统计学差异。采用酶联免疫吸附法、免疫比浊法分别检测各组的血清IL-6、hs-CRP。结果:与正常老年组对比,老年MCI组的IL-6显著升高(P<0.01),hs-CRP水平显著升高(P<0.05)。结论:老年轻度认知功能障碍可能与炎症密切相关,IL-6、hs-CRP作为促炎因子可能起着重要作用。IL-6可能是预测老年MCI更灵敏的指标。
Objective： To investigate the correlations between interleukin-6（IL-6）, high sensitive C-reactive protein（hs-CPR） and mild cognitive impairment（MCI） in senior patients. Methods： One hundred senior patients suffering from mild cognitive impairment（MCI） were compared with 100 healthy senior controls. No significant differences were found in essential hypertension, diabetic mellitus, smoking, dyslipidemia, alcohol drinking, body mass index and teaching background between the two groups. Levels of serum IL-6 and hs-CRP were measured by enzyme-linked immunosorbent assay（ELISA） and immunoturbidimetry（ITM）, respectively. Results： Compared with healthy control group, level of IL-6in MCI patients was increased very significantly（P 〈0.01） and level of hs-CRP was increased significantly（P 〈0.05）.Conclusions： MCI in elderly patients may be related to inflammatory course, serum IL-6 and hs-CRP as pro-inflammatory factors might play very important roles in MCI. Increased serum IL-6 probably is a sensitive marker for predicting MCI in elderly, and further studies are needed.
出处
《诊断学理论与实践》
2014年第4期416-418,共3页
Journal of Diagnostics Concepts & Practice
基金
新疆生产建设兵团科学技术局资助(2012BA052)
