摘要
目的采用Meta分析评价右美托咪定对心脏手术患者术中MAP与HR的影响。方法计算机检索PubMed、Embase、Cochrane图书馆、CNKI、CBM和万方数据库,收集有关右美托咪定用于心脏手术患者的随机对照试验（RCT）,检索时限均从建库至2014年2月,同时检索纳入研究的参考文献。采用Cochrane质量标准评价所纳入文献的质量。评价指标包括给药至手术结束期间MAP、HR和不良反应（高血压、心动过速）,采用RevMan 5.1软件进行Meta分析。结果纳入19项研究,共758例患者,结果显示右美托咪定可降低心脏手术患者术中高血压（OR=0.22,95%CI0.13~0.36）和心动过速（OR=0.24,95%CI 0.12~0.48）的发生率（P〈0.05）。结论右美托咪定可降低心脏手术患者术中高血压及心动过速的发生率,能较好地维持术中循环稳定。
Objective To estimate the effectiveness and safety of using dexmedetomidine on MAP and HR in patients undergoing cardiac surgery. Methods A systematic search （PubMed, Em- base, Cochrane Library, CNKI, CBM and WanFang Database）, up to February 2014, was performed for randomized controlled trials （RCT） comparisons of dexmedetomidine with saline. Revman 5.1 software provided by the Cochrane Collaboration was used for Meta-analysis. MAP, HR and adverse reactions such as hypertension, tachycardia from using drugs to the end of operation were evaluate. Results A total of 758 patients undergoing cardiac surgery from 19 trials were subjected to Meta-a- nalysis. In comparison with normal saline, dexrnedetomidine reduced perioperative heart rate and blood pressure, and reduced the incidence of hypertension （OR=0. 22, 95 %CI 0. 13-0.36） and tachy- cardia （OR=0.24, 95GCI 0. 12-0. 48） （P〈0. 05）. Conclusion With the limited data, using dexme- detomidine in patients undergoing cardiac surgery appears to be safer and it may maintain stable circu- lation and reduce the incidence of hypertension and tachycardia.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2015年第2期125-130,共6页
Journal of Clinical Anesthesiology
