期刊文献+

恶性肿瘤与高凝状态 被引量:9

Tumors with Hypercoagulable State
在线阅读 下载PDF
导出
摘要 恶性肿瘤是严重危害人类健康的疾病,目前恶性肿瘤的发生发展机制尚未明确,恶性肿瘤的发展是一个涉及多因素多步骤的复杂的生物学过程,进一步研究恶性肿瘤的发生发展机制,为临床干预恶性肿瘤提供实验依据,成为目前面临的机遇和挑战。恶性肿瘤常伴随血液高凝状态,且高凝状态与恶性肿瘤的临床病理状态及预后相关。本文综述了近年来国内外的有关文献,旨在揭示恶性肿瘤与高凝状态之间的相关机制。 Malignancy tumors are of great damages to human health.At present,the mechanism leading to tumors are still remains undetermined.The invitation and progression of tumor is a complex progress involves many factors and procedures.Detecting the invitation and progression mechanisms of tumor can provide experimental data for clinical treatment,which became a great challenge.Tumors always accompany with hypercoagulable state,moreover,such hypercoagulable state has been proved to relate to clincopathological stages and recovery after treatment.This artical summarized the reasarching achievement in and aborad aiming at expounding the corelation between malignancy tumor and hypercoagulable state.
作者 辛士珍 王燕
出处 《四川解剖学杂志》 2014年第3期37-41,共5页 Sichuan Journal of Anatomy
关键词 恶性肿瘤 高凝状态 凝血活性物质 Malignancy tumor Hypercoagulable state Clotting active substances
  • 相关文献

参考文献42

  • 1Trousseau A. Phlegmasia alba dolens In: Clinique Medicale de L'Hotel-Dieu Paris [M]. London, New Sydenham Socie- ty, 865: 94-96.
  • 2Gou in-Thibault I,A chkar A,Sam am a MM. The thrombo- philic state in cancer patients [J] Acta Haemato, 2001,106 (1-2) :33-42.
  • 3Goro KOSAKI, Junichi KAMBAYASHIT hrombocytogenesis by megakaryocyte Interpretation by protoplatelet hypothe- sis. 2011 : 87,254-273.
  • 4Hsu-Lin SC, Cindy LB, Barbara CF, et al. A platelet mem- brane protein expressed during platelet activation and Secre- tion [J] Journal of biological chemistry, 1884, 259 (14): 9121-8126.
  • 5Moore K L. Structure and function o{ P-selectin glycoprotein ligand-1 [J] Leuk. Lymphoma,1998:29:1-15.
  • 6Trikha M,Nakada MT. Platelets and callcer. "implications for antiangiogcnic therapy [J]. Seminars in Thrombosis And Hc- mostasis,2002 :28,39-44.
  • 7Salgado R, Vermeulen PB, Benoy I et al. Platelet number and interleukin-6 correlate with VEGF but not with bFGF se- rum levels of advanced cancer patients [J]. Br J Cancer , 1999,80: 892-897.
  • 8Benoy I, Salgado R, Colpaert C, Wcytjens R, Vermculcn PB, Dirix LY. Serum interlcukin 6, plasma VEGF, serum VEGF, and VEGF platelet load in breast cancer patients [J]. Clin Breast Cancer ,2002,2: 311-315.
  • 9Kim HK, Song KS, Park YS, et al. Elevated levels of circu- lating platelet micropartieles, VEGF, IL-6 and RANTES in patients with gastric cancert possible role of a metastasis pre- dictor [J]. Eur J Cancer , 2003,39,184-191.
  • 10Verheul HM, Jorna AS, Hoekman K, et al. Vascular endo- thelial growth factor-stimulated endothelial ceils promote ad- hesion and activation of platelets [J]. Blood, 2000,96 : 4216- 4221.

二级参考文献38

  • 1李龙芸,路刚.肺动脉栓塞25例临床分析[J].中华内科杂志,1993,32(9):583-586. 被引量:20
  • 2晋雯,林志武,高美钦,杨代兴.P选择素在结直肠癌的表达及临床意义[J].福建医科大学学报,2005,39(2):159-161. 被引量:1
  • 3万远廉,戎龙,刘玉村,姚宏伟,汪欣,吴涛,潘义生,朱静.组织因子对大肠癌细胞侵袭及血行转移的影响[J].中华外科杂志,2005,43(19):1265-1267. 被引量:9
  • 4陈金联,周同,吴云林,王瑞年,魏子白,翟祖康.P-选择素在胃癌中表达及其预后意义[J].上海医学,1996,19(5):249-251. 被引量:9
  • 5Michael R,D'Andrea,Claudia K,et al.Differential expression of protease-activated receptors-1 and-2 in stromal fibroblasts of normal,benign,and malignant human tissues[J].Am J Pathol,2001,158(6):2031-2041.
  • 6Maragoudakis ME,Kraniti N,Giannopoulou E,et al.Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists[J].Endothelium,2001,8(3):195-205.
  • 7Dalila Darmoul,Valérie Gratio,Hélène Devud,et al.Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induced cell proliferation and motility in human colon cancer cells[J].Am J Pathol,2003,162(5):1503-1513.
  • 8Takashi Minami,Md.Ruhul Abid,Jie Zhang,et al.Aird Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein Kinase C (PKC)-δ-NF-κB and PKC-ζ-GATA signaling pathways[J].J Biol Chem,2003,278(9):6976-6984.
  • 9Sharona Cohen Even-Ram,Miriam Maoz,Elisheva Pokroy,et al.Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the αvβ5 Integrin[J].J Biol Chem,2001,276(14):10952-10962.
  • 10Harris H,Kirschenlohr H,Szabados N,et al.Transforming growth factor-betal inhits thrombin activation of endothelial cells[J].Cytokine,2004,25(3):85-93.

共引文献117

同被引文献132

引证文献9

二级引证文献58

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部