摘要
目的 探讨P选择素在结直肠癌细胞的表达情况与临床病理关系及预后的意义。 方法 应用链酶素生物素(SP)免疫组织化学法,对6 2例结直肠癌及5例正常肠黏膜进行P选择素的检测。 结果 P选择素在正常组织中未见表达,在结直肠癌组织中阳性表达率为6 7.74 % ,其阳性表达与患者的性别、肿瘤的组织分型、分化程度均无关,与癌性血栓形成及Dukes分期有关(P <0 .0 5 )。P选择素阳性者5年生存率及平均生存期[5 2 .38% ,(33.33±18.5 2 )月]均低于P选择素阴性者[80 .0 0 % ,(5 0 .83±15 .2 3)月,P <0 .0 5 ]。 结论 P选择素在结直肠癌中的高表达与肿瘤的转移潜能有关,对判断结直肠癌的预后有参考价值。
Objective To study the expression of P-selectin in colorectal neoplasms and its relationship with clinicopathological parameters and prognosis. Methods 62 colorectal neoplasms and 5 normal colonic mucosae were examined for P-selectin with SP immunohistochemical technique. Results The expression of selectin P was negative in normal colonic mucosae. Positive-rate of P-selectin was 67.74% in colorectal carcinoma. The expression of P-selectin was not correlated with sex, histological patterns and differentiated degree of cancer. But was significantly correlated to tumor thrombus and Duke's stages(P<0.05). The five-year survival rate and survival time were lower in P-selectin positive cases[52.38%, (33.33±8.52)m] than in negative cases[ 80.00% , (50.83±15.23)m, P<0.05]. Conclusion The expression of P-selectin was correlated to the metastatic potentiality of human colorectal carcinoma and may be useful in predicting the metastasis and prognosis in human colorectal tumor.
出处
《福建医科大学学报》
2005年第2期159-161,i002,共4页
Journal of Fujian Medical University
基金
福建省教育厅科研基金资助项目 (JA0 10 63 )
关键词
结直肠肿瘤
P选择素
肿瘤转移
预后
colorectal neoplasms
P-selectin
neoplasms metastasis
prognosis
