摘要
目的:观察5-氨基酮戊酸光动力疗法(5-ALA-PDT)治疗皮肤癌前病变和浅表皮肤肿瘤的疗效。方法:对7例日光性角化病、5例基底细胞癌、2例鲍温病、1例乳房外paget病患者进行5-氨基酮戊酸光动力疗法(5-ALA-PDT)治疗。结果:随访6个月,7例日光性角化病患者中,6例患者皮损获得完全缓解,1例部分缓解;5例基底细胞癌患者中,2例完全缓解,2例部分缓解,1例无反应。2例鲍温病患者均获得完全缓解;1例乳房外paget病患者部分缓解。结论:使用5-ALA-PDT治疗皮肤肿瘤,疗效好、痛苦小、美容效果满意,特别适合一般情况差,难以耐受手术的特殊患者,可在临床工作中进一步推广。
Objective：To investigate the effects of 5-aminolaevulinic acid-photodynamic therapy（ 5-ALA-PDT）on precancerous changes and superficial skin cancer. Methods：Seven patients with actinic keratosis（ AK）,5 patients with basal cell cancer（ BCC）,2 patients with Bowen＆#39;s disease and 1 patient with extramammary Pagetˊs dis-ease were given topical 5-ALA followed by PDT. Results：After followed-up for 6 months,7 patients with AK,2 pa-tients with BCC,2 patients with Bowen＆#39;s disease achieved complete remission（ CR）,1 patient with AK,2 patients with BCC,1 patient with extramammary Pagetˊs disease achieved partial remission（ PR）. No response was observed in BCC patients. Conclusion：Topical 5-ALA-PDT is a simple,effective and new treatment with excellent cosmetic re-sults for precancerous changes and superficial skin cancer.
出处
《现代肿瘤医学》
CAS
2014年第10期2447-2448,共2页
Journal of Modern Oncology
关键词
氨基酮戊酸
皮肤癌前病变
浅表皮肤肿瘤
光动力疗法
5-aminolevulinic acid
precancerous changes
superficial skin cancer
photodynamic therapy
