摘要
目的观察麻黄附子细辛汤联合依巴斯汀治疗脾虚湿蕴证慢性自发性荨麻疹(CSU)的临床疗效及安全性。方法选取2017年1月—2018年12月河南省中医院皮肤科门诊收治的88例CSU患者为研究对象。采用随机数字表法将其分为观察组与对照组,各44例。对照组给予依巴斯汀片口服,观察组在对照组的基础上给予麻黄附子细辛汤,以4周为1个疗程。比较两组治疗前后各症状(瘙痒、风团数目、风团直径、风团出现频率、风团持续时间)积分,临床疗效,治疗前后血清组胺、免疫球蛋白E(IgE)水平,治疗前后皮肤病生活质量指数量表(DLQI)评分,不良反应情况,复发情况。结果治疗后,观察组瘙痒、风团数目、风团直径、风团出现频率、风团持续时间积分低于对照组(P<0.05);两组治疗后瘙痒、风团数目、风团直径、风团出现频率、风团持续时间积分均低于本组治疗前(P<0.05)。观察组临床疗效优于对照组(P<0.05);观察组总有效率高于对照组(P<0.05)。治疗后,观察组血清组胺、IgE水平低于对照组(P<0.05);两组治疗后血清组胺、IgE水平均低于本组治疗前(P<0.05)。治疗后,观察组DLQI评分低于对照组(P<0.05);两组治疗后DLQI评分均低于本组治疗前(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。观察组复发率低于对照组(P<0.05)。结论麻黄附子细辛汤联合依巴斯汀治疗脾虚湿蕴证CSU患者疗效确切,在症状改善、临床疗效、炎性指标、生活质量等改善上均优于单独依巴斯汀片治疗,且安全性好,复发率低,值得临床推广应用。
Objective To observe the clinical efficacy and safety of Mahuang Fuzi Xixin decoction combined with ebastine in the treatment of chronic spontaneous urticaria(CSU)with spleen deficiency and accumulated dampness syndrome.Methods 88 CSU patients admitted to the Dermatology Clinic of Henan Province Hospital of TCM from January 2017 to December 2018 were selected and divided into observation group and control group according to the random number table method,with 44 cases in each group.The control group was given ebastine tablet orally,and the observation group was given Mahuang Fuzi Asarum decoction on the basis of the control group,with 4 weeks as a course of treatment.The scores of symptoms(pruritus,and number,diameter,frequency and duration of wheal)before and after treatment,clinical efficacy,serum histamine and immunoglobulin E(IGE)levels before and after treatment,Dermatology Life Quality Index(DLQI)scores before and after treatment,adverse reactions and recurrence were compared between the two groups.Results After treatment,the scores of pruritus,wheal number,wheal diameter,wheal frequency and wheal duration in the observation group were significantly lower than those in control group(P<0.05).The scores of pruritus,wheal number,wheal diameter,wheal frequency and wheal duration in the two groups after treatment were lower than those before treatment(P<0.05).The clinical effect of the observation group was better than that of the control group(P<0.05),and the total effective rate of the observation group was higher than that of the control group(P<0.05).The levels of serum histamine and IgE in observation group were significantly lower than those in control group(P<0.05),and the levels of serum histamine and IgE after treatment in the two groups were significantly lower than those before treatment(P<0.05).the DLQI score in observation group was significantly lower than that in control group(P<0.05),and the DLQI score after treatment in the two groups was significantly lower than that before treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Mahuang Fuzi Xixin decoction combined with ebastine has exact efficacy in the treatment of patients with spleen deficiency and accumulated dampness syndrome of CSU.And it is superior to ebastine alone in improving symptoms,clinical efficacy,inflammatory indexes and quality of life.What’s more,it has good safety and low recurrence rate,and is worthy of clinical application.
作者
徐俊涛
王莹
王丽
刘爱民
方玉甫
Li;LIU Aimin;FANG Yufu(Henan Province Hospital of TCM,Zhengzhou 450003,China)
出处
《中国全科医学》
CAS
北大核心
2019年第S02期142-145,共4页
Chinese General Practice
关键词
荨麻疹
慢性自发性荨麻疹
脾虚湿蕴证
依巴斯汀
麻黄附子细辛汤
疗效
安全性
Urticaria
Chronic spontaneous urticaria
Spleen deficiency and accumulated dampness syndrome
Ebastine
Mahuang Fuzi Xixin decoction
Efficacy
Safety
