摘要
目的探讨乙型肝炎病毒X基因(HBX)在涎腺腺样囊性癌(ACC)中的表达及意义。方法选取2008年6月—2012年10月就诊于昆明医科大学附属口腔医院口腔颌面外科的涎腺肿瘤患者为研究对象。血清学结果HBeAg无论是阳性或阴性,以HBeAb阳性为HBV携带者或曾感染者。根据术后病理结果分为ACC组和对照组,采用免疫组织化学及聚合酶链反应(PCR)技术检测两组组织中HBX的表达。结果 HBX大多数表达于细胞质内,小部分表达于胞核内。HBX在ACC中表达强度强于涎腺腺淋巴瘤,二者间差异有统计学意义。结论 HBX在ACC的发生、发展中可能起重要作用。
Objective To explore the expression of hepatitis B-virus X gene （HBX） in adenoid cystic carcinoma （ACC） and determine its clinical significance. Methods Between June 2008 and October 2012, in-hospital patients with salivary gland tumors who were treated at the Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, were enrolled to this study. HBeAb-positive patients were defined as those exposed to hepatitis B virus （HBV） or harboring persistent HBV infection regardless of being HBeAg positive or negative. According to the pathological results, all patients were divided into ACC group and control group. Immunohistochemical staining and polymerase chain reaction （PCR） were used to detect HBX expression in ACC group and control group. Results HBX expression was mostly detected in the cytoplasm of ACC cells. Minimal HBX expression was detected in the nucleus. HBX expression was significantly higher in ACC than in Warthin’s tumor. A significant difference was observed between the two groups. Conclusion HBX is expressed in ACC and may be associated with the development of ACC. HBX might serve important functions in the carcinogenesis and development of ACC.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2014年第4期328-330,共3页
West China Journal of Stomatology
基金
云南省科技厅-昆明医科大学联合专项基金资助项目(20-11FB211
2011FB163)
云南省高层次卫生技术人才专项基金资助项目(D-201233)
