摘要
目的分析本院常见G-菌对氨曲南的耐药情况,为临床合理使用氨曲南提供参考依据。方法收集本院2010年1月~2013年12月患者标本中分离出来的2 485株病原菌对氨曲南的药敏试验结果,并对该结果进行统计处理,结合具体用药原因分析本院常见G-菌对氨曲南的耐药性。结果本院大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌、铜绿假单胞菌、阴沟肠杆菌以及不动杆菌属等6种主要G-菌对氨曲南的耐药率分别由2010年的44.05%、50.32%、10.00%、19.23%、48.72%和13.26%上升到2013年的64.42%、70.83%、17.69%、34.78%、65.38%和25.00%;上升比例分别为45.83%、40.75%、76.90%、80.86%、34.20%和88.54%。结论本院上述6种G-菌对氨曲南的耐药率呈逐年上升趋势,其中奇异变形杆菌、铜绿假单胞菌以及不动杆菌属对氨曲南的耐药率上升比例最快;本院临床要严格掌握该药适应证,限制其不合理应用。
Objective To analyze the drug-resistance of common gram-negative bacteria to aztreonam in our hospital,and to provide reference for the rational use of aztreonam.Methods We collected the susceptibility test results of 2 485 pathogens to aztreonam isolated out of the patients＇ specimens from January 2010 to December 2013.The author processed the results with statistical method to analyze the drug-resistance of common gram-negative bacteria to aztreonam.ResultsThe rate of the drug-resistance to aztreonam of the 6 major gram-negative bacteria such as E.coli,K.pneumoniae,P.mirabilis,P.aeruginosa,E.cloacae and Acinetobacter in our hospital rose respectively from 44.05%,50.32%,10.00%,19.23%,48.72% and 13.26% in 2010 to 64.42%,70.83%,17.69%,34.78%,65.38% and 25.00% in 2013.The rising proportion of the drug-resistance to aztreonam of the above 6 gram-negative bacteria was 45.83%,40.75%,76.90%,80.86%,34.20% and 88.54% in 4 years.Conclusion The rate of the above 6 gram-negative bacteria drug-resistance to aztreonam increases gradually and yearly in our hospital.The rate of the drug-resistance to aztreonam of P.mirabilis,P.aeruginosa and Acinetobacter rise the fastest.Clinical use of aztreonam should be strictly controlled.
出处
《中南药学》
CAS
2014年第7期716-720,共5页
Central South Pharmacy
关键词
氨曲南
革兰阴性菌
耐药率
不合理用药
aztreonam
gram-negative bacteria
resistance rate
irrational drug use
