摘要
为了探讨有氧运动辅助常规药物对治疗原发性高血压患者血压和血管内皮功能影响,本研究选取2010年4月至2013年12月本院收治的140例原发性高血压患者,采用抛掷硬币的方法随机分为对照组和治疗组各70例,两组患者均采用硝苯地平联合厄贝沙坦治疗、饮食控制等措施,治疗组患者在医生指导下进行有氧运动,比较两组患者的血压控制情况以及反映高血压患者血管内皮功能的指标血清中一氧化氮(nitric oxide,NO)、内皮素-1 (endothelin-1, ET-1)、基质金属蛋白酶28 (matrixmetalloproteinase-28, MMP-28)、超敏C反应蛋白(high-sensitive C-reactive protein, hs-CRP)水平,通过血流介导的血管扩张(flow mediateddilation, FMD)和硝酸甘油介导的血管扩张反应(nitroglycerin-mediateddilation, NMD)检测血管内皮功能。治疗前,比较两组患者的收缩压(systolic blood pressure, SBP)和舒张压(diastolic blood pressure, DBP)测定值无显著性差异(p>0.05);治疗后,治疗组患者的SBP和DBP测定值均明显低于对照组(p<0.05);治疗前,比较两组患者的ET-1、NO、hs-CRP、MMP-28的水平均无明显差异(p>0.05);治疗后,治疗组患者的ET-1、hs-CRP、MMP-28的水平均明显低于对照组(p<0.05),治疗组患者NO水平明显高于对照组(p<0.05);治疗前,两组患者的FMD、NMD无明显差异(p>0.05);治疗后,治疗组患者的FMD、NMD明显高于对照组(p<0.05);治疗后,治疗组患者显效88.57%、有效11.43%,对照组显效74.29%、有效25.71%,两组患者比较具有明显差异(p<0.05)。有氧运动辅助常规药物治疗原发性高血压患者有助于进一步降低血压、减轻高血压状态对患者血管内皮功能的损伤。
To investigate the effects of aerobic exercises on blood pressure and endothelial function in patients with essential hypertension, this study selected forty patients with essential hypertension who were admitted to our hospital from April 2010 to December 2013, and randomly divided into the control group and the treatment group with 70 cases each by tossing coin. Both groups were treated with nifedipine combined with Eritrea Beisutan treatment, diet control and other measures. The patients in the treatment group underwent aerobic exercise under the guidance of doctors. This study compared the level of nitric oxide(NO), Endothelin-1(ET-1), matrixmetalloproteinase-28(MMP-28) and high-sensitive C-reactive protein(hs-CRP), which reflected the indexes of vascular endothelial function in patients with hypertension. And we detected vascular endothelial function by flow-mediated dilation(FMD) and nitroglycerin-mediated diathesis(NMD). There was no significant difference in systolic blood pressure(SBP) and diastolic blood pressure(DBP) between the two groups before treatment(p >0.05). Aftertreatment, the estimated value of SBP and DBP in the treatment group were significantly higher than the control group(p<0.05). Before treatment, the levels of ET-1, NO, hs-CRP and MMP-28 in the two groups had no significant difference(p>0.05). After treatment, the levels of ET-1, hs-CRP and MMP-28 were significantly lower in the treatment group than those in the control group( p>0.05), and the levels of NO in the treatment group were significantly higher than those in the control group(p>0.05)(p>0.05). After treatment, the FMD and NMD in the treatment group were significantly higher than those in the control group(p>0.05). After treatment, the effective rate of the treatment group was 88.57% and the effective rate was 11.43%. Markedly effective 74.29%, effective 25.71%,the two groups had significant differences(p>0.05). Aerobic exercise aids routine drug therapy in patients with essential hypertension could help further reduce blood pressure and reduce the state of hypertension in patients with vascular endothelial dysfunction.
作者
吕绍昆
邹开文
丁绍平
Lu Shaokun;Zou Kaiwen;Ding Shaoping(First People's hospital of Qujing City,Qujing,655000)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第2期772-778,共7页
Genomics and Applied Biology
关键词
有氧运动
原发性高血压
血管内皮功能
Aerobic exercise
Essential hypertension
Vascular endothelial function
