摘要
皮肤瘙痒是许多皮肤原发性疾病和系统性疾病常见的临床症状,严重影响患者的生活质量。随着对瘙痒的不断研究,人类对瘙痒的认识及治疗上取得了新的进展,但是具体的发生机制仍不清楚,皮肤瘙痒在治疗上仍然面临巨大的挑战。因此,了解其的发生机制,并探索中药、尤其是活性成分对皮肤瘙痒的治疗引起研究者的浓厚兴趣。中药资源丰富、活性成分结构多样,在皮肤瘙痒的治疗上具有广阔的前景。本文通过查阅近年来国内外相关文献,重点综述了皮肤源性瘙痒神经传导通路及外周致痒介质产生瘙痒的机制,并综述了针对这些机制的中药活性成分治疗瘙痒的研究报道,旨在为进一步提高皮肤瘙痒的治疗效果提供参考。
The skin Pruritus is a common clinical symptom of many primary and systemic skin diseases.It seriously affects the quality of life of patients.New progress has been made in the understanding and treatment of pruritus with further research on pruritus.However,the treatment of pruritus is still facing great challenges due to the unclear mechanism.Therefore,understanding its mechanism,exploring the Chinese medicine of the treatment of pruritus and especially the active ingredient arouses great interest of the researchers.The treatment of itchy skin has broad prospects due to the rich resources of traditional chinese medicine and the diverse active ingredients.In this paper,through reviewing the relevant literatures around the world in recent years,the mechanisms of skin-derived pruritus and peripheram pruritus are reviewed.The research reports on the pruritus treatment with these active ingredients are summarized.All this provides references for improving the treatment effect of itchy skin.
作者
黄蓓
万君晗
吴永秋
黄传利
杨健峰
张彩凤
龙晓英
HUANG Bei;WAN Jun-han;WU Yong-qiu;HUANG Chuan-li;YANG Jian-feng;ZHANG Cai-feng;LONG Xiao-ying(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou510006,China)
出处
《海峡药学》
2018年第12期1-6,共6页
Strait Pharmaceutical Journal
关键词
皮肤瘙痒
机制
瘙痒介质
中药有效成分
Pruritus
mechanism
Medium
Active ingredients of traditional Chinese medicine
