摘要
目的检验行非体外循环不停跳冠状动脉搭桥患者术后静脉应用肝素钠抗凝治疗后,其体内肌钙蛋白T水平的变化。方法收集2014年1月至2016年6月间行非体外循环不停跳冠状动脉搭桥患者病例资料。其中2015年3月以后手术患者术后常规经静脉注射肝素钠行抗凝治疗为试验组; 2015年3月以前手术患者术后未应用肝素钠抗凝为对照组。2组患者手术方式、术前准备及术后其余治疗方案均相同。比较2组术后肌钙蛋白T水平的变化。结果试验组术后肌钙蛋白T明显低于对照组(P <0. 05),并且试验组相对于对照组下降更迅速。结论在非体外循环不停跳冠状动脉搭桥术后在激活全血凝固时间指导下,经静脉持续给予肝素钠的患者肌钙蛋白T增高幅度减少,提示可以降低心肌损伤。
AIM To examine the changes of cardiac troponin T ( TNT) level in patients with intravenousheparin sodium therapy early after off-pump coronary artery bypass. METHODS Data of patients undergoing off-pump coronary artery bypass grafting in our hospital from January 2014 to June 2016 were collected. Test results ofTNT level were compared between patients who were routinely injected with heparin sodium after coronary artery by-pass grafting after March 2015 as experimental group and patients who were not given heparin sodium before March2015 as control group. RESULTS TNT in the experimental group was significantly lower and decreased morerapidly than in the control group on the first three days after the operation( P <0. 05) . CONCLUSION The de-crease of troponin T in patients after off-pump coronary artery bypass grafting with continuous intravenous heparin in-fusion under the guidance of activation of whole blood coagulation time indicates that it can reduce myocardial injury.
作者
谷小卫
董自超
南晓松
姚伟
杜虹
GU Xiaowei;DONG Zichao;NAN Xiaosong;YAO Wei;DU Hong(Department of Cardiac Surgery,Ninety-first PLA Central Hospital,Henan Province,Jiaozuo 454003,Chin)
出处
《中国临床药学杂志》
CAS
2018年第6期384-387,共4页
Chinese Journal of Clinical Pharmacy
关键词
肌钙蛋白T
肝素钠
非体外循环
冠状动脉搭桥术
cardiac troponin T
heparin sodium
off-pump
coronary artery bypass grafting
