摘要
目的:探讨在不同儿童消化道疾病中幽门螺杆菌(Hp)的现症感染率,同时比较13C呼气试验(13C-UBT)、快速尿素酶检测(RUT)及Warthin-Starry(W-S)银染色病理检测三种检测方法在儿童Hp感染中的临床价值。方法:选取2017年11月至2018年3月在南京医科大学附属儿童医院进行胃镜检查儿童120例,所选患儿在胃镜前1月内皆进行13C-UBT检测且未经治疗,在胃镜检查过程中取胃窦黏膜标本进行RUT检测,然后送病理科进行W-S银染色病理检测Hp感染,判断是否为Hp现症感染。结果:行胃镜检查120例儿童中,13C-UBT检测阳性58例,阴性62例; RUT检测阳性59例,阴性61例; W-S银染色病理检测阳性63例,阴性57例。根据诊断标准最终诊断Hp现症感染阳性率55. 8%(67/120),13C-UBT、RUT、W-S银染色病理检测符合率分别为90. 8%、88. 3%、91. 7%。不同儿童消化道疾病中Hp现症感染率不同,其中结节性胃炎感染率最高,达到87. 5%,其次是结节性胃炎合并十二指肠溃疡,感染率76. 9%,而胆汁反流性胃炎感染率最低,仅为11. 1%。结论:三种Hp检测方法的一致性较高,无创方法13C-UBT值得临床更广泛的使用;不同消化道疾病儿童的Hp现症感染率差异明显。
Objective: To investigate the current infection rate of Helicobacter pylori in different children’s digestive tract diseases,and to compare the clinical value of13 C breath test(13 C-UBT),rapid urease test(RUT) and Warthin-Starry(WS) silver staining pathological examination in children with H. pylori infection. Methods: A total of 120 children undergoing gastroscopy admitted into Nanjing Children’s Hospital Affiliated to Nanjing Medical University from Nov. 2017 to Mar. 2018 were extracted. All the selected children underwent13 C-UBTt test within 1 month before gastroscopy without treatment,during the process of gastroscopy,the gastric sinus mucosa specimens were taken for RUT detection,and then sent to the pathology department for WS silver staining pathological detection of H.pylori infection. Results: Of the 120 children with gastroscopy,58 were positive for13 C-UBT and 62 were negative; 59 were positive for RUT,61 were negative; 63 were positive for WS silver staining and 57 were negative. According to the standard diagnostic criteria,the final H.pylori infection rate was 55.8%(67/120). The coincidence rate of13 C-UBT,RUT and WS silver staining was 90.8%,88.3% and 91.7%,respectively. The infection rate of H.pylori was different in different children’s digestive tract diseases,among which the nodular gastritis infection rate was the highest,reaching 87.5%,followed by nodular gastritis with duodenal ulcer,the infection rate was 76.9%,and the infection rate of bile reflux gastritis was the lowest,only 11.1%. Conclusion: The consistency of the three H.pylori detection methods is relatively high,and the non-invasive method13 C-UBT is worthy of widely clinical application; the infection rate of H.pylori in children with different digestive diseases is significantly different.
作者
肖欢庆
陆田田
王春莉
郑必霞
练敏
武海燕
金玉
刘志峰
Xiao Huanqing;Lu Tiantian;Wang Chunli;Zheng Bixia;Lian Min;Wu Haiyan;Jin Yu;Liu Zhifeng(Suqian People's Hospital of Nanjing Durra-Tower Hospital Group of Nanjing University School of Medicine,Suqian Municipal People's Hospital,Jiangsu Suqian 223800,China;Nanjing Children's Hospital Affiliated to Nanjing Medical University,Jiangsu Nanjing 223800,China)
出处
《儿科药学杂志》
CAS
2018年第12期19-22,共4页
Journal of Pediatric Pharmacy
关键词
儿童
幽门螺杆菌
检测方法
现症感染率
消化道疾病
children
Helicobacter pylori
detection method
infection rate
digestive diseases
