摘要
AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly.
AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between co...
作者
Qu, Xin-Hua
Huang, Xiao-Lu
Xiong, Ping
Zhu, Cui-Ying
Huang, You-Liang
Lu, Lun-Gen
Sun, Xu
Rong, Lan
Zhong, Liang
Sun, Da-Yu
Lin, Hai
Cai, Ming-Ci
Chen, Zhi-Wei
Hu, Bing
Wu, Lian-Ming
Jiang, Yi-Bin
Yan, Wei-Li
基金
Supported by(in part)The National Natural Science Foundation of China,No.30770599
China Postdoctoral Science Foundation,No.2005038143
Shanghai Municipal Education Commission,No.09YZ82
Shanghai Leading Academic Discipline Project,No.S30203
