摘要
目的 探讨血管内皮生长因子 (VEGF)在妊娠高血压综合征 (妊高征 )患者血清及其分娩的新生儿脐血中的表达。方法 用酶联免疫吸附法检测 46例妊高征患者 (妊高征组 )外周血及其分娩的新生儿脐血VEGF水平 ,并与 40例健康孕妇 (非妊高征组 )及其分娩的新生儿 (对照组 )对比分析。结果 妊高征组外周血VEGF水平为 ( 9.3± 2 .8)ng·L-1,明显低于对照组的 ( 16 .8± 9.6 )ng·L-1(P <0 .0 1)。妊高征组的新生儿脐血VEGF水平为 ( 4 2 .4± 13.7)ng·L-1,低于对照组新生儿的 ( 75 .3± 15 .7)ng·L-1(P <0 .0 5 )。结论 妊高征患者血清及其分娩的新生儿脐血中VEGF减少可能是妊高征血管病变的原因之一。
Objective To clarify the expression of vascular endothelial growth factor(VEGF) in serum of women with pregnancy induced hypertension(PIH) and umbilical blood from their newborns.Method Enzyme linked immunosorbent assay was used to measured serum VEGF from 46 women with pregnancy induced hypertension and their newborns(PIH group).40 normal pregnany women and their newborns (normal group).The later group was as control.Results The VEGF level in PIH group was (9.3±2.8)ng·L -1 ,significantly lower than that in normal group 〔VEGF level was (16.8±9.6)ng·L -1 , P <0.01〕.The VEGF level in umbilical blood of newborns from PIH was (42.4± 13.7 )ng·L -1 ,significantly lower than that in of newborns from normal group 〔VEGF level was (75.3±15.7)ng·L -1 , P <0.05〕.Conclusion The VEGF reduction in serum of women with PIH and umbilical blood from newborns may be one of the reasons of pathologic change of blood vessels.
出处
《铁道医学》
2002年第1期18-19,共2页
Railway Medical Journal
关键词
血管内皮生长因子
妊娠高血压综合征
胎儿
新生儿
脐血
基因表达
vascular endothelial growth factor
pregnancy complications,cardiovascular
hypertension
newborn
umbilical blood
