摘要
目的 探讨金尔伦 (盐酸纳洛酮 )对重型头伤后脑组织内Ca2 + 、Mg2 + 、EAA及血浆ET变化的影响及临床意义。方法 SD大鼠 72只 ,随机分为治疗组、对照组及空白组。参照Feeny自由落体撞击法建立头伤模型 ,伤后半小时 ,治疗组大鼠于腹腔注射金尔伦 10mg/kg;对照组大鼠则于腹腔注射生理盐水 10mg/kg ;空白组不作任何处理。按伤后处理时间各组再分为 4小组 ,每组 6只 ,分别于伤后 1小时 ,2小时 ,4小时 ,8小时处死 1小组 ,检测损伤区脑组织内Ca2 + 、Mg2 + 、EAA及ET含量。结果 治疗组伤后Ca2 + 、EAA和ET含量轻度升高 ,Mg2 + 含量下降不明显 ,与对照组相比有统计学差异。结论 金尔伦通过竞争性拮抗内源性阿片肽受体 ,能明显逆转实验动物重型头伤后损伤区脑组织内Ca2 + 、EAA和ET含量的增高及Mg2 + 的下降 ,具有脑保护作用。其详细机理有待进一步研究。
Objective To investigate the effect of Naloxone on the change of content of Ca 2+ 、Mg 2+ and EAA in brain tissue and ET in plasma after severe head injury. Methods 72 SD rats were divided into three groups randomly. (empty group, control group and trial group). Refering to the free falling body crash divice of Feenly, the head injury model was established. The rats of trial group were injected with Naloxone transpeniponeally by 10mg per kilogram half an hour, meanwhile after half an hour the same amount of normal saline was given to the control group. And the empty group were subjected to no disposal. Every group was divided into 4 sub groups according to the posttraumatic disposal time. Every sub group was composed of 6 SD rats and killed at the point of 1 hour, 2 hour, 4 hour and 8 hour after injury respectively, Then the content of Ca 2+ 、Mg 2+ and EAA in brain tissue and ET in plasma were measured. Results The post traumatic content of Ca 2+ 、EAA and ET of trial group increased mildly and the Mg 2+ reduced very little. There was a significant statistical difference between the trial group and the control group. Conclusions For experimental animals by antagonzing the endogenous opium recepor competitively, Naloxone may significantly reverse the rise in the content of Ca 2+ and EAA and the fall of Mg 2+ and the increment of ET in plasma as well after severe brain injury. As a result, Naloxone possesses protective effect on brain. But its detailed mechanism is still in need for further research.
出处
《中华神经外科杂志》
CSCD
北大核心
2001年第3期140-142,共3页
Chinese Journal of Neurosurgery
