摘要
目的 探究功能性消化不良应用多潘立酮联合盐酸多塞平治疗的临床可行性和安全性。方法 选择2011年9月～2013年9月湖州市中心医院收治的功能性消化不良患者96例，按随机数字表方法 分成两组，每组48例，对照组给予多潘立酮，研究组给予盐酸多塞平联合多潘立酮治疗，分析两组疗效、症状评分、复发和不良反应情况。结果 研究组的有效率为91．67％，高于对照组的64．58％，两组比较差异有统计学意义（P〈0．05）；治疗后两组胃部灼烧感、饭后饱胀、上腹痛以及嗳气等症状评分均比治疗前低（P〈0．05）；且研究组的胃部烧灼感、饭后饱胀和上腹痛评分比对照组低，差异有统计学意义（P〈0．05）；研究组复发率（12．50％）显著低于对照组（31．25％），差异有统计学意义（P〈0．05）。结论 盐酸多塞平与多潘立酮联合治疗功能性消化不良患者效果明显，症状改善明显且生活质量良好，具有一定的临床研究和应用价值。
Objective To explore the feasibility and safety of Domperidone combined with Doxepin in the treatment of functional dyspepsia. Methods 96 cases of patients with functional dyspepsia admitted to Huzhou Central Hospital from September 2011 to September 2013 was selected and divided into two groups according to random number table, with 48 cases in each group, the control group was given Domperidone, the study group was treated with Doxepin and Domperidone. The curative effect, symptom scores, recurrence and adverse reactions of two groups were analyzed. Results The effective rate of study group was 91.67%, which was higher than the control group （64.58%）, the difference was statistically significant （P 〈 0.05）; after treatment, the symptom scores of stomach burning, flautulence after a meal, epigastric pain and belching in the two groups were all lower than before treatment （P 〈 0.05）, and the scores of stom- ach burning, flautulence after a meal, epigastric pain in the study group were lower than those of control group, with statistically significant differences （P 〈 0.05）; the recurrence rate of study group （12.50%） was lower than that of control group （31.25%）, with a statistically significant difference （P 〈 0.05）. Conclusion Domperidone combined with Doxepin in the treatment of functional dyspepsia has an obvious effect, improvement of symptoms is significant, and quality of life is good, which has certain clinical research and application value.
出处
《中国医药导报》
CAS
2014年第14期60-62,73,共4页
China Medical Herald
基金
浙江省湖州市科技计划项目(编号2008YS13)
