摘要
多发性骨髓瘤（MM）细胞克隆性增殖涉及细胞内多个信号通路.环腺苷酸（cAMP）信号通路作为一种重要的细胞内信息传递系统,与包括骨髓瘤细胞在内的多种恶性淋巴细胞增殖和凋亡的失调相关.靶向调变cAMP信号通路可以诱导包括骨髓瘤细胞在内的多种恶性淋巴细胞增殖阻滞和凋亡,其机制涉及线粒体介导细胞凋亡和cAMP调控多种细胞内递质.对cAMP介导骨髓瘤细胞凋亡深入研究分析,将为临床治疗MM提供可能途径和潜在靶点.
The clonal proliferations of multiple myeloma cells consist of several signaling pathways.It has been shown that cyclic adenosine monophosphate （cAMP） signaling pathway,an important intra-cellular messenger delivery system,is related to abnormal proliferation and apoptosis of malignant lymphoid cells including myeloma cells.Manipulating the cAMP signaling pathway could induce cell cycle arrest and apoptosis of various malignant lymphoid cells including myeloma cells,which involve mitochondrial-dependent apoptosis and cAMP-modulated changes of intra-cellular mediators.In-depth researches and analysis of cAMP-induced apoptosis in myeloma cells would provide potential targets and possible therapeutic means in the treatment of multiple myeloma.
出处
《国际肿瘤学杂志》
CAS
2014年第5期368-370,共3页
Journal of International Oncology
基金
上海市自然科学基金（12ZR1416800）
上海市卫生局科研课题（2010101）
