摘要
目的:探讨麻疹疫苗(measles vaccine)联合CHOP方案治疗弥漫大B细胞淋巴瘤(DLBCL)的临床疗效和毒副反应。方法:选择2006年1月至2011年12月住院治疗的DLBCL患者60例,随机分为观察组(30例)和对照组(30例),观察组采用麻疹疫苗联合CHOP方案治疗,对照组采用单纯CHOP方案化疗。全部患者完成6个周期化疗。比较两组治疗效果,随访观察生存情况。结果:观察组总有效(OR)率(CR+PR)为83.3%(25/30),对照组总有效(OR)率(CR+PR)为60%(18/30),比较差异有显著性(P<0.05)。观察组和对照组1年PFS率为76.7%及50%(P<0.05),1年总生存率为90%及66.7%(P<0.05)。结论:麻疹疫苗联合CHOP方案治疗弥漫大B细胞淋巴瘤有安全、有效、不良反应少、生存率高等优点,值得进一步研究。
Objective：To evaluate the efficacy and toxicity of combination chemotherapy consisting of lneasles vac- cine and CHOP for patients with diffuse large B - cell lylnpholna（DLBCL）. Methods：All 60 patients with DLBCL hospitalized froln January 2006 to Deeelnber 2011 were randomly assigned to receive either CHOP plus lneasles vac- cine （study group） or CHOP alone （ control group）. All of the patients have received 6 chemotherapy cycles. Results ： The overall respone （OR） rate was 83.3% （25/30） in the study group,and the OR rate was 60% （18/30） in the control group,with an obvious difference between the two groups （P 〈 0.05）. The 1 - year progression free survial were 76.7% and 50% in two groups （P 〈 0.05 ）. The 1 -year overall ssurvial rates were 90% and 66.7 % in two groups （ P 〈 0.05 ）. Conclusion ： Combination chemotherapy including measles vaccine and CHOP is effecitive and safe in treatment for DLBCL,fewer adverse reactions,and a higher survival rate.
出处
《现代肿瘤医学》
CAS
2014年第3期643-645,共3页
Journal of Modern Oncology
基金
山东省重点科技计划项目(编号:2006GG2302008)
关键词
麻疹疫苗
弥漫大B细胞淋巴瘤
化疗
measles vaccine
diffuse large B - cell lympholna
chemotherapy
