摘要
目的:扁桃体是淋巴结外恶性淋巴瘤的好发部位,本研究对扁桃体恶性淋巴瘤的临床特点和预后因素进行分析,探讨临床指标与预后的关系。方法:对我院1990年1月至2000年12月收治的26例原发于扁桃体的恶性淋巴瘤患者的临床特点,预后因素、治疗进行总结,并结合文献进行分析。结果:本组扁桃体恶性淋巴瘤患者以中老年居多,病理均为非霍奇金淋巴瘤(non-hodgkin'slymphoma,NHL)。中高度恶性居多。全组5年总生存率、癌症相关生存率、无瘤生存率分别为68%、70.8%、61%。死亡15例,12例死于肿瘤本身,3例死于并发症。Cox多因素分析显示,年龄、国际预后指数(internationalprognosticIndex,IPI)、血清乳酸脱氢酶(serumlactatedehydrogenase,LDH)、一般状况和分期是影响预后的独立因素。结论:原发于扁桃体的非霍奇金淋巴瘤,年龄、IPI、LDH、一般状况和分期是预后的重要指标。早期发现,早期治疗是提高生存率的重要途径。
Objective： The most common site of extranodular type non - Hodgkin＇s lymphoma（NHL） is the palatine tonsil. The purpose of this study was to investigate the clinical features and prognostic factors of NHL of the tonsil. Methods：Twenty - six patients with primary NHL of tonsil were treated between Jan. 1990 to Dec. 2000. Clinical data（age,pathologic features,stage,etc. ）,and treatment results and prognostic factors were investigated. Results：More patients were over 50 years old,all patients were pathologically proven to be NHL . The 5 - year overall survival rate,cancer specific survival rate and disease - free survival rate were 68% ,70.8%, 61%. 15 patients died,12 died of tumor,3 died of complication. Multivariate analysis showed that age, international prognostic index, serum lactate dehydrogenase, general status and clinical stage were independent prognostic factors. Conclusion：Age, international prognostic index, general status and clinical stage are important prognostic factors for NHL of the tonsil. Diagnosis early ,treatment early is the important way to improve the prognosis.
出处
《现代肿瘤医学》
CAS
2007年第1期15-18,共4页
Journal of Modern Oncology
关键词
扁桃体
非霍奇金淋巴瘤
治疗
预后因素
tonsil
non - Hodgkin＇s lymphoma
therapy
prognostic factor
