摘要
目的:观察术中泵注右美托咪定(Dex)对全麻下行乳腺癌手术患者术后疼痛的影响。方法:择期行全麻乳腺癌手术患者60例,ASAⅠ级或Ⅱ级,随机分为观察组和对照组各30例。观察组于术中以0.4μg/(kg·h)持续泵注右美托咪定;对照组以同样的方式泵注等量生理盐水。术中均采用丙泊酚、瑞芬太尼和舒芬太尼全凭静脉麻醉。于术后不同时点采用视觉模拟评分法(VAS)评价术后镇痛效果及记录术后不良反应。结果:观察组VAS评分明显低于对照组(P<0.05),观察组不良反应发生率明显低于对照组。结论:持续泵注右美托咪定用于全麻下乳腺癌手术术后镇痛时可明显提高镇痛效果,减少相关不良反应,可作为全麻基础辅助药选用。
Objective：To investigate the postoperative analgesic effect of dexmedetomidine in patients undergoing radical mastectomy under general anesthesia. Methods： Sixty patients with ASA I or 1I, scheduled for radical masteetomy under general anesthesia, were randomly divided into 2 groups （n = 30 ）： dexmedetomidine group （ group D） and control group （ group C ）. Dexmedetomidine was intravenously infused at a rate of 0.4 μg/（ kg h） during the operation in group D and the same volume of normal saline was infused in group C. Anesthesia was maintained by propofol, remifentanil and sufentanil. The postoperative surgical pain was assessed by Visual Analogue Scale （VAS） after the orientation recovery, postoperative adverse reaction was recorded. Results： VAS was significantly lower after the orientation recovery in group D than group C （ P 〈 0.05 ）. The adverse reaction was significantly lower in group D than in group C. Conclusion： Dexmedetomidine can provides more satisfactory and comfortable postoperative analgesia for patients undergoing radical mastectomy, can reduce the adverse reaction, can be used as a general base auxiliary agents.
出处
《现代临床医学》
2014年第2期106-107,共2页
Journal of Modern Clinical Medicine
关键词
右美托咪定
术后镇痛
乳腺癌根治术
dexmedetomidine
postoperative analgesia
radical masteetomy
