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四跨膜蛋白超家族与肿瘤侵袭和转移 被引量：2

Relationships of Transmembrane 4 Superfamily to Tumor Invasion and Metastasis
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摘要 四跨膜蛋白超家族包括20个家族成员,以4个高度保守的跨膜结构为特征的蛋白家族。四跨膜蛋白通过与细胞表面多种跨膜蛋白形成复合物,而广泛参与调控细胞生长、黏附、迁移和信号转导等生物学功能,且高表达的四跨膜蛋白CD151、TM4SF5与肝癌、胃癌及乳腺癌的侵袭和转移有关。 Transmembrane 4 superfamily （TM4SF） consists of more than 20 family members, which are characterized by four highly conserved transmembrane structures. TM4SF proteins are involved in the regulation of cell growth, adhesion, migration and signal transduction through forming complexes with other transmembrane proteins. The high levels of CD151 and TM4SF5 are associated with the invasion and metastasis of liver,stomach and breast cancer.
作者 吴永兵 徐建军
机构地区 南昌大学第二附属医院心胸外科
出处 《南昌大学学报（医学版）》 CAS 2013年第11期89-93,共5页 Journal of Nanchang University：Medical Sciences
关键词 四跨膜蛋白 四跨膜蛋白超家族 肿瘤侵袭 肿瘤转移 生物学功能 tetraspanin transmembrane 4 superfamily tumor invasion tumor metastasis biological function
分类号 R73-37 [医药卫生—肿瘤] Q786 [生物学—分子生物学]
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参考文献41

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同被引文献27

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南昌大学学报（医学版）
2013年 第11期

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