摘要
目的:观察补虚通痹法(肺纤通方)对特发性肺间质纤维化患者生活质量的影响。方法:将48例患者随机分为两组,治疗组予以肺纤通方治疗,对照组予以N-乙酰半胱氨酸治疗,比较两组患者圣·乔治呼吸问题调查问卷评分、6 min步行试验及呼吸困难症状评分的变化。结果:在圣·乔治呼吸问题调查问卷综合评定方面,治疗组明显优于对照组(P<0.05),总评分、症状评分、心理状况评分方面,治疗组在治疗后较治疗前均有明显改善(P<0.05),组间比较,治疗组有优于对照组的趋势,但差异无统计学意义(P>0.05);两组患者治疗前后6 min步行距离均有延长,但治疗组延长程度明显优于对照组(P<0.05);在患者呼吸困难症状方面,治疗组明显优于对照组(P<0.05)。结论:补虚通痹法(肺纤通方)能够明显改善患者呼吸困难的症状,提高特发性肺间质纤维化患者生活质量及增强患者活动耐力。
Objective： To observe the effect of the Qi-Tonifying and Stagnation-Purging Method（ Feixiantong decoction） on life quality of Idiopathic Pulmonary Fibrosis（ IPF） patients. Methods： 48 IPF patients were randomly divided into two groups,the treatment group treated with Feixiantong decoction and the control group treated with NAC for 3 months. We collected the score of SGRQ,6-minutes walk result and breathing difficulty score before and after the treatment,established a database and analyzed data with SAS 8. 2. Results： Com- pared to control group,the treatment group improved significantly at the comprehensive assessment of SGRQ. There was significant im- provement of the treatment group in terms of total score,symptom score,psychological status score about SGRQ after treatment,but the difference was not significant compared to the control group. The treatment group also showed significantly better effect in the 6 minutes walk test and difficulty breathing integral score. Conclusion： The patients with IPF can benefit from the treatment of the decoction of Feixiantong by relieving difficulty breathing,improving patient＇s quality of life and physical endurance.
出处
《世界中医药》
CAS
2013年第12期1433-1435,共3页
World Chinese Medicine
基金
国家自然科学基金-基于"痹-虚"病机基础的配伍中药干预肺纤维化大鼠的机理研究(编号:30901948)
北京市科学技术委员会课题-肺纤通方提高特发性肺间质纤维化患者活动耐力的临床研究(编号:Z131107002213053)
中国中医科学院西苑医院院内课题-肺纤通对特发性肺间质纤维化患者(气阴两虚
肺络闭阻证)运动耐力影响的临床研究(编号:xyky-mp-05)
关键词
补虚通痹法
肺纤通方
特发性肺间质纤维化
生活质量
Qi-Tonifying and Stagnation-Purging Method
Idiopathic Pulmonary Fibrosis
Feixiantong Decoction
Quality of Life
