摘要
目的对比分析阿德福韦酯与拉米夫定治疗乙型肝炎肝纤维化的临床效果。方法选取我院自2006年10月至2012年10月期间收治的乙型肝炎肝纤维化患者98例,作为临床研究对象。将所有患者进行随机分组,每组各49例,试验组患者采用阿德福韦酯治疗,对照组患者采用拉米夫定治疗。记录并比较两组患者治疗15个月后Child-Pugh分级评情况。结果试验组患者治疗后Child-Pugh分级评分明显优于对照组,A级得分人数比例(83.67%)明显高对照组(67.3 5%),P<0.05,具有统计学意义。结论临床上采用阿德福韦酯治疗乙型肝炎肝纤维化优势明显,疗效优于拉米夫定治疗组,不良反应发生少,患者肝功能指标情况良好,有一定的临床优势,值得推广使用。
Objective To compare and analyse the clinical effects of adefovir dipivoxil and lanaivudine（LAM） on flyer fibrosis of hepatitis B, Methods 98 patients with liver fibrosis of hepatitis B in our hospital from October 2006 to October 2012 were selected as clinical study objects, All patients were randomly divided into two group, 49 cases in each group, the experimental group wore treated with adefovir diptvoxil,the control group were treated with lamivudine. Recorded and compared the Child-Pugh grading-score conditions of two group patients after 15 months of treatment, Results The Child-Pugh grading-score of experimental group patients after treatroent were significantly better Shan the control goup,and the A score percentage of experimental group （83.67 %） was significamly higher than control group （67.32 %）,P〈0.05,the results wore statistically singnifcant, Conclusions It has obvious advantages to apply adefovir dipivoxil in the treatmem of liver fibrosis of hepatitis B in clinic, which is more effective than lamivudine treatment group, with fewer adverse reactions, liver function indexes of patients is good, having certain clinical advantages, it should be promoted.
出处
《中国医药指南》
2014年第1期39-40,共2页
Guide of China Medicine
关键词
乙型肝炎肝纤维化
阿德福韦酯
拉米夫定
临床疗效
Liver fibrosis of hepatitis B
Adefovir dipivoxil
Lamivudine
Clinical efficacy
