摘要
目的:观察维甘乳膏联合维生素B6治疗卡培他滨相关手足综合征的疗效与安全性。方法:选择56例结、直肠癌或胃癌患者,均采用卡培他滨为主的化疗方案治疗,所有患者在化疗过程中共出现手足综合征105次(同一患者可重复出现),按照症状出现次数随机分为治疗组(53次)与对照组(52次)。对照组患者仅口服维生素B630 mg,tid;治疗组患者在对照组基础上外用维甘乳膏涂抹于局部,一日4次。两组患者均用药至恢复正常。观察比较患者手足综合征毒性等级以及治疗过程中的不良反应发生情况。结果:卡培他滨相关手足综合征的发生例数在不同年龄、性别和肿瘤类型间的差异无统计学意义(P>0.05)。治疗组总有效率(88.7%)显著高于对照组(63.5%),两组比较差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:维甘乳膏联合维生素B6治疗卡培他滨相关手足综合征疗效和安全性均较好,可以提高患者对化疗的耐受性。
OBJECTIVE： To observe therapeutic efficacy of Weigan cream combined with vitamin B6 in the treatment of capecitabine related hand foot syndrome （HFS）. METHODS： 56 patients who had been diagnosed by pathological or cytological of colorectal cancer or gastric cancer were treated by capecitabine, while 105 times HFS happened （same patient may suffered from the symptoms repeatedly）. Those patients were randomly divided into treatment group （53 times） and control group （52 times） according to the number of symptom occurrence. Control group was given vitamin B,, orally ＇30 mg, 3 times a day; treatment group was additionally given Weigan Cream for local use 4 times a day on the basis of control group. 2 groups returned to normal after treatment. Whether HFS toxicity was downgraded were compared and ADR were also observed during treatment. RESULTS：There was no statistical significance in the case number of capecitabine related HFS in different age, gender and tumer type groups （P〉 0.05）. The total effective rate of treatment group（88.7% ） was higher than that of control group（ 63.5%）; there was statistical significance （P〈0.05）. The incidence of ADR in 2 groups had no statistical significance（P〉0.05）. CONCLUSIONS： Weigan Cream combined with vitamin B6 has ideal treatment effect on hand foot syndrome caused by capecitabine, and improve patients＇ tolerance to chemotherapy.
出处
《中国药房》
CAS
CSCD
2013年第48期4529-4531,共3页
China Pharmacy
基金
国家自然科学基金资助项目(No.81272556)
广东省科学事业费专项项目(No.2010B060900016)
