摘要
目的探讨病毒性脑炎患儿脑脊液S-100b蛋白、神经元特异性烯醇化酶(NSE)和白细胞介素-6(IL-6)含量变化及其临床意义。方法采用酶联免疫吸附试验(ELISA)检测病毒性脑炎患儿急性期和恢复期脑脊液S-100b蛋白与IL-6水平,采用电化学发光法(ECLI)检测NSE的水平,并与正常对照组进行比较分析。结果病毒性脑炎患儿脑脊液S-100b蛋白、NSE和IL-6含量急性期明显高于正常对照组(P<0.01);重症组其水平明显高于轻症组,轻症组明显高于正常对照组(P<0.01)。结论病毒性脑炎患儿脑脊液S-100b蛋白、NSE和IL-6均显著升高,其水平与疾病的发生发展和病情的严重程度有关。
Objective To explore the changes and clinical significance of S - 100b protein, NSE and IL - 6 in the development of viral encephalitis. Methods The levels of S - 100b protein and IL - 6 in CSF were detected by ELISA in acute phase and recovery phase, and the NSE level was detected with ECLI, then the levels were compared with normal children. Results The cerebrospinal fluid levels of S - 100b protein, NSE and IL -5 in the patients in acute stage were significantly higher than those of normal children（ P 〈 0.01 ）. The levels of severe cases were significantly higher than those of mild cases, while those of mild cases were significantly higher than those in normal children （P 〈 0.01 ）. Conclusion The levels of S - 100b protein, NSE and IL - 6 in children with viral encephalitis raise significantly, related with the advance and the condition of viral encephalitis.
出处
《中国卫生检验杂志》
北大核心
2013年第16期3235-3236,共2页
Chinese Journal of Health Laboratory Technology
