摘要
目的:探讨鼠神经生长因子治疗病毒性脑炎的效果及对认知功能的影响。方法:选择2016年1月至2016年10月诊治的病毒性脑炎患者160例作为研究对象,随机分为观察组与对照组,各80例,对照组给予常规治疗,观察组在对照组治疗的基础上给予鼠神经生长因子辅助治疗,两组都持续治疗14 d,观察两组患者的治疗效果。结果:观察组患者的体温降至正常时间、抽搐控制时间、昏迷转清醒时间、肢体运动障碍恢复时间少于对照组(P<0.05)。治疗后,两组患者的简易智力检查量表(mini-mental state examination,MMSE)评分均高于治疗前(P<0.05),且观察组患者的MMSE评分高于对照组(P<0.05)。两组患者在治疗过程中均发生不同程度的呕吐、腹泻、皮疹、恶心等,总发生率分别为2.5%和3.8%,两组患者不良反应发生率对比,差异无统计学意义(P>0.05)。结论:鼠神经生长因子辅助治疗病毒性脑炎临床效果较好,安全性较高,可促进认知功能的恢复。
Objective： To discuss the effect of mouse nerve growth factor in the treatment of viral encephalitis and its influence on cognitive function. Methods： t60 cases of patients with viral encephalitis from January 2016 to October 2016 were randomly divided into observation group and control group, 80 cases in each group. The patients in control group were treated with conventional therapy, and those in observation group were added adjuvant therapy of mouse nerve growth factor. The treatment duration was 14 days and the therapeutic effects in the two groups were observed and compared. Results： The time of body temperature drop to normal, tic control time, wakening hours from a coma, and limbs dyskinesia recovery time in observation group were significantly shorter than those in control group （ P 〈 0. 05 ）. MMSE scores after therapy in the two groups were significantly higher than those before therapy （ P 〈 0.05）, and MMSE score in observation group was signifi- cantly higher than that in control group （ P 〈 0.05 ）. There was no difference in the incidence of emesis, diarrhea, rash and nausea （2.5 % and 3.8 % respectively in observation group and control group ; P 〉 0.05 ）. Conclusion ： Mouse nerve growth factor in the treatment of viral encephalitis, with higher security and good clini- cal effect, can promote the recovery of cognitive function.
作者
刘朝锋
LIU Chaofeng(Nanshi Hospital of Nanyang, Nanyang 473000, Chin)
出处
《包头医学院学报》
CAS
2017年第6期51-53,共3页
Journal of Baotou Medical College
关键词
鼠神经生长因子
病毒性脑炎
认知功能
不良反应
Mouse nerve growth factor
Viral encephalitis
Cognitive function
Adverse reaction
