摘要
目的:了解儿童抗生素相关性腹泻病(AAD)的危险因素。方法:对2011年9月8日～15日在湖北省妇幼保健院儿科住院的儿童采用横断面分析,随访60天,分成有抗生素相关性腹泻(观察组)和无抗生素相关性腹泻(对照组)两组,比较两组年龄、营养状况、免疫功能状况、原发疾病、抗生素使用频率及种类等情况,并进行多因素Logistic回归分析。结果:随访60天,出现AAD者78例,AAD发生率为27.76%。两组年龄构成(P<0.05)、营养状况(P<0.05)、免疫功能状况(P<0.05)、原发疾病(P<0.05)、AAD组抗生素使用种类(P<0.05)及抗生素使用时间(P<0.05)等方面两组比较差异均有统计学意义。患儿的免疫功能状态和抗生素使用种类是AAD的危险因素。结论:在使用抗生素的儿童中,年龄越小、营养不良及免疫功能不良、使用抗生素的时间越长,种类越多出现AAD几率越高,免疫功能低下和不合理使用抗生素是AAD的危险因素,积极的支持治疗及使用益生菌可以减少ADD的发生。
Objective： To understand the risk factors of antibiotic - associated diarrhea （AAD） in children. Methods ： The hospi- talized children in the hospital from 8th to 15th September 2011 were analyzed by cross -section analysis, then they were followed up for 60 days and divided into AAD group （observation group） and non- AAD group （control group） ; the age, nutritional statuses, immune func- tions, original diseases, application frequencies and types of antibiotics in the two groups were compared, multivariate logistic regression a- nalysis was used to analyze the data. Results： The children were followed up for 60 days, 78 children were diagnosed as ADD, the inci- dence rate of ADD was 27.76% ; there were statistically significant differences in the age structure, nutritional status, immune function, o- riginal diseases, application frequency and time of antibiotics between the two groups （ P 〈 O. 05 ） ; immune function and application types of antibiotics were risk factors of ADD. Conclusion： Among the children treated with antibiotics, the children with low age, malnutrition, im- mune dysfunction, long application time and more application types of antibiotics have high incidence rate of ADD ; immune dysfunction and unreasonable application of antibiotics were risk factors of ADD, active supportive treatment and applying probiotics can reduce the incidence rate of ADD.
出处
《中国妇幼保健》
CAS
北大核心
2013年第34期5658-5660,共3页
Maternal and Child Health Care of China
基金
湖北省自然科学基金项目〔2009CDZ021〕
关键词
抗生素相关性腹泻
儿童
危险因素
Antibiotic - associated diarrhea
Child
Risk factor
