摘要
目的 探讨比索洛尔（Bisoprolol Fumarate）联合依那普利（Enalapril maleate tablets）治疗原发性高血压（essential hypertension）的临床疗效以及用药安全性.方法 收集2011年5月至2013年5月本院收治的96例原发性高血压患者,随机分为对照组和观察组各48例.对照组予依那 普利5 ～ 10mg,每日2次口服；观察组在对照组服药方案基础上加用比索洛尔2.5～5 mg,每日1次口服,以4周为1个疗程.监测患者治疗前后的血压、心率、尿常规、血常规、肝功能、肾功能,并且记录患者服药期间产生的不良反应.结果 观察组总有效率为93.75％,对照组总有效率为81.25％,观察组总有效率高于对照组,差异有统计学意义（x 2=3.4,P＜0.05）.两组患者在本研究过程中未出现心脑事件,也未发现低血压,心率、血常规、尿常规、肝肾功能均在正常范围.结论 依那普利联合比索洛尔治疗原发性高血压具有理想的临床疗效,不良反应少.
Objective To investigate the clinical efficacy and drug safety of Bisoprolol fumarate combined with Enalapril maleate tablets in essential hypertension.Methods From May 2011 to May 2013,we collected 96 patients with primary hypertension,by random drawing method,they were divided into the control group and the treatment group with 48 cases in each group.The control group was treated with Enalapril 5-10 mg,orally twice a day,the observation group was treated with Bisoprolol medication scheme for 2.5-5 mg,oral once daily,4 weeks as a course of treatment,blood pressure of patients before and after treatment,as well as the heart rate monitor,urine routine,blood routine,liver function,renal function,and adverse reactions were recorded during the medication.Results In the observation group,the total efficiency was 93.75％,the total effective rate of control group was 81.25％,total effective rate of observation group was higher than that of the control group,with significant difference between the two groups （x 2=3.4,P ＜ 0.05）.No cardiovascular events occurred in the process of the research,no blood pressure found,heart rate,blood routine,urine routine,liver and kidney function were within the normal range.Conclusion The clinicat curative effect of Enalapril combined with Bisoprolol in the treatment of essential hypertension is ideal,with less adverse reaction.
出处
《国际医药卫生导报》
2013年第22期3435-3438,共4页
International Medicine and Health Guidance News
