摘要
【目的】探讨于浅表淋巴结射频消融术(RFA)中,采用不同方法在皮下注射生理盐水形成隔离带对兔皮肤免受热损伤的有效性及差异性。【方法】21只新西兰大白兔建立兔腘窝反应增生性淋巴结模型后,分为3组(每组7只):A组为对照组,未行皮下注射生理盐水制造隔离带;B组于RFA术前在淋巴结局部皮下行一次性注射生理盐水5 mL制造隔离带,C组于RFA术前在淋巴结局部皮下先行注射生理盐水1 mL,术中接注射泵按1 mL/min持续注射生理盐水。各组实验动物均在腘窝淋巴结内行RFA术,术后行超声造影(CEUS)测量消融灶范围,并于术后1 h及1周观察皮肤损伤情况。【结果】B组与C组消融灶较小,A组较大(P<0.01)。RFA术后1 h及术后1周,A组皮肤损伤较严重(P<0.01),B组可出现轻度皮肤损伤,C组未出现明显皮肤损伤。【结论】对浅表淋巴结行RFA术前在皮下注射生理盐水形成隔离带对皮肤能起到较好的保护作用,而采用持续性注水的方式保护作用较稳定。
[Objective] To explore protective effect of different patterns to form local isolation subcutaneously which prevent rabbits skin defending thermal injury during Radiofrequency ablation （RFA） process of superficial lymph nodes. [Methods] 21 New Zealand white rabbits established reactive hyperplasic lymph nodes in bilateral popliteal fossa, were divided into 3 groups （n = 7）： Group A, performed RFA without injected physiological saline solution subcutaneously to form local isolation. Group B, injected 5 mL physiological saline solution subcutaneously near lymph node before RFA： Group C, injected 1 mL physiological saline solution subcutaneously near lymph node before RFA, and followed by continuous injection of physiological saline solution using syringe pump with 1 mL/min during RFA process. Contrast-enhanced ultrasonography （CEUS） was performed after RFA and the area of lesions were measured ; skin injury was observed in 1 hour and 1 week later after RFA. [ Results ] CEUS showed the RFA lesions of A group was larger （P 〈 0.01）. For the skin change of 1 hour and 1 week later, A group showed the most serious injury （P 〈 0.01）, while B group and C group appeared slighter injury. [Conclusions] Subcutaneous injection of physiological saline solution to form local isolation before RFA in the superficial lymph nodes can protect the skin effectively, and the effect of continuous injection will be more helpful.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2013年第5期712-717,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
珠海市医学科研基金(2012021)
关键词
浅表淋巴结
射频消融
皮肤损伤
superficial lymph nodes
radiofrequency ablation
skin injury
