摘要
目的研究黎族T2DM患者载脂蛋白E(ApoE)基因多态性及血糖、血脂水平的变化,探讨其与疾病的相关性。方法选取黎族T2DM患者(T2DM组)121例及健康对照者(NC组)112名,应用聚合酶链式反应-限制性核酸内切酶片段长度多态性(PCR-RFLP)进行ApoE基因分型,并对患者病程、BMI、血糖、血脂水平进行分析。结果 T2DM组_ε3等位基因频率低于NC组(P<0.05),TC、LDL-C水平高于NC组(P<0.01),T2DM组等位基因_ε3亚组LDL-C水平低于_ε2亚组,_ε2亚组TG水平高于_ε3、_ε4亚组,脂蛋白(a)[Lp(a)]水平低于_ε3、_ε4亚组(P<0.05)。结论 ApoE e3等位基因对黎族T2DM发生有一定的拮抗作用,且脂代谢与ApoE基因多态性有一定关系。
Objective To study the change in serum lipids and glucose levels and apolipoprotein E （ApoE） gene polymorphism in the Li population T2DM patients to identify their correlations with each other. Methods ApoE genotypes of 121 patients in Li population T2DM patients and 112 normal controls （NC） were identified by PCR-RFLP, and the course, BMI, and the levels of serum lipids and glucose were analyzed. Results The allele ε3 frequency of the Li population T2DM patients was lower than that of NC （P〈0. 05）, the levels of TC and LDL-C in the Li population T2DM patients were higher than those in NC （P〈0. 01）, the level of LDL-C in the allele ε3 subgroup of the Li population T2DM patients was lower than that in the allele ε2 subgroup, the lever of TG in the allele ε2 subgroup of the Li population T2DM patients was higher than that in the ε3 and ε4 subgroups, and the level of Lp（a） in the allele ε2 subgroup was lower than that of the ε3 and ε4 subgroups （P〈0.05）. Conclusion The allele ε3 acts as a protection factor for the Li population T2DM patients, and there is a relation between lipid metabolism and ApoE polymorphism.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2013年第9期822-824,共3页
Chinese Journal of Diabetes
关键词
黎族
糖尿病
2型
血脂
载脂蛋白E
基因多态性
Li populatiom Diabetes mellitus, type 2 Serum lipid
Apolipoprotein E （ApoE） Polymorphism
