摘要
目的了解慢性丙型肝炎患者采用聚乙二醇干扰素α-2a联合利巴韦林治疗期间情绪障碍发生情况及心理干预效果。方法抗丙型肝炎病毒(聚乙二醇干扰素α-2a联合利巴韦林)治疗的96例慢性丙型肝炎患者分为心理干预组和对照组各48例,心理干预组每周1次心理干预。采用症状自评量表(SCL-90)对所有患者进行评定,分析两组患者SCL-90的分值变化并和中国成人常模对比。结果对照组SCL-90躯体化(t=2.68,P<0.01)、焦虑(t=1.99,P<0.05)、抑郁(t=1.72,P<0.05)、人际关系(t=1.71,P<0.05)和精神病性(t=1.85,P<0.05)等因子得分与中国成人常模比较有显著性差异。干预组SCL-90躯体化(t=2.72,P<0.01)、焦虑(t=1.97,P<0.05)、抑郁(t=2.02,P<0.05)、精神病性(t=1.93,P<0.05)等因子得分与中国成人常模比较有显著性差异。但心理干预组和对照组相比较,心理干预措施能显著性改善患者情绪障碍,心理干预组和对照组抑郁得分(t=1.74,P<0.05)、焦虑得分(t=1.82,P<0.05)和精神病性得分(t=1.91,P<0.05)有显著性差异。结论慢性丙型肝炎患者及其在聚乙二醇干扰素α-2a联合利巴韦林治疗期间存在躯体化、焦虑、抑郁等心理问题,心理干预对改善患者情绪障碍有积极作用。
Objective To understand the emotional disturbance arising during the period of treatment with pegylated interferon -α-2a plus ribavirin in patients with chronic hepatitis C,and effects of psychological intervention. Methods A total of 96 pa- tients with chronic hepatitis C who were treated by anti--HCV drugs（pegylated Interferon-α-2a plus ribavirin）were divided into psychological intervention group （48 patients）and comparison group （48 patients）,psychological intervention measures were taken for the psychological intervention group once every week. All the patients will be assessed by way of Symptom Checklist 90（SCL-- 90）in order to analyze the change in scores of the SCL--90 items of these two groups in comparison with the norm of the Chinese adults. Results Factors scores in somatization（t=2.68,P（0. 01）,anxiety（t= 1.99,P〈0.05）,depression（t=l. 72,P（0.05）, interpersonal relationship（t= 1.71 ,P（0.05）and psychotic item（t： 1.85 ,P〈0.05）of patients with chronic hepatitis C during the treatment period of pegylated interferon-α-2a plus ribavirin were higher than the norm of the Chinese adults. Factors scores in somatization （t = 2.72, P 〈 0. 01 ）, anxiety （t =1.97, P〈 0.05）, depression （t = 2.02, P〈 0.05 ） and psychotic item （t = 1.93, P〈 0.05）of patients in the psychological intervention group were also higher than the norm of the Chinese adults significantly. But compared the psychological intervention group with the comparison group,taking psychological intervention measures for such pa- tients could substantially improve patients＇ emotional disturbance, factors scores in depression （t = 1. 74, P〈 0. 05 ）, anxiety （t = 1.82,P〈0.05）and psychotic item（t=1.91,P〈0. 05）were significantly different between two groups. Conclusion During the period of treatment with pegylated interferon-α-2a plus ribavirin,patients with chronic hepatitis C have psychological problem such as somatization,anxiety and depression. Psychological intervention measures have positive effects on improvement of patients＇ emotional disturbance.
出处
《中国健康心理学杂志》
2013年第9期1304-1306,共3页
China Journal of Health Psychology
