摘要
目的探讨无乳糖奶粉联合酪酸梭菌活菌散治疗轮状病毒性肠炎的临床疗效。方法将187例腹泻患儿随机分为A、B、C 3组,A组给予常规治疗,配合母乳或普通配方奶粉喂养;B组在A组药物治疗基础上联合酪酸梭菌活菌散口服;C组采用B组药物治疗方法,并改用无乳糖奶粉喂养,禁食其他含乳糖制品,于腹泻停止后继续喂养3 d。比较3组患儿临床症状消失时间、住院时间、血清和大便白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平、不良反应及复发率。结果 B、C组临床症状消失时间及住院时间均显著短于A组,C组时间减少更为显著;3组患儿血清和大便IL-8及TNF-α水平均较治疗前显著降低,其中C组降低最为明显;A组3个月复发率显著高于B、C组,而B组3个月复发率有高于C组的趋势;治疗期间,3组均未发现药物相关性不良反应。结论在常规治疗基础上,联合应用无乳糖奶粉及酪酸梭菌活菌散治疗轮状病毒性肠炎患儿可有效缩短临床症状消失时间及住院时间,减轻肠道炎症,降低复发率,且安全性好。
Objective To discuss the clinical effects of milk powder free of lactose combined with clostridium butyricum powder in the treatment of rotavirus enteritis.Methods One hundred and eighty-seven children with diarrhea were randomly divided into groups A,B,C.Group A was treated conventionally together with breast milk or common formulas,group B was given clostridium butyricum powder on the basis of treatment in group A and group C was fed with milk powder free of lactose based on the treatment of group B and free of other lactose products.The treatment continued for three days after the disappearance of diarrhea.The disappearance time of clinical symptoms,hospital stays,levels of interleukin 8（IL-8） and tumor necrosis factor α（TNF-α） in serum and defecation,adverse reactions and recurrence rate of three groups were compared.Results The disappearance time of clinical symptoms and hospital stays in groups B and C were significantly shorter than those in group A,in which the decreased time in group C was the most significant.The levels of IL-8 and TNF-α in serum and defecation in three groups significantly reduced after treatment,in which the reduction of group C was the most remarkable.The recurrence rate of group A was obviously higher than that of groups B and C in three months,while that of group B was slightly higher than group C.During treatment,the adverse reactions related to drugs were not be found in three groups.Conclusion On the basis of conventional therapy,the combination of milk powder free of lactose and clostridium butyricum powder in the treatment of children with rotavirus enteritis can effectively shorten the disappearance time of clinical symptoms and hospital stays,relieve the enteritis and reduce the recurrence rate with good safety.
出处
《实用临床医药杂志》
CAS
2013年第13期162-165,共4页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321003)
关键词
无乳糖奶粉
酪酸梭菌活菌散
轮状病毒性肠炎
炎症因子
milk powder free of lactose
clostridium butyricum powder
rotavirus enteritis
inflammatory factor
